Re: !!

From: Zach Newton (zbnewton@mindspring.com)
Mon May 1 17:29:27 2000


Rafael Haciski MD wrote:

> It is quite reasonable to assume that there are naturally and spontaneously
> occurring situations when the progesterone drops below levels necessary for
> sustenance of the pregnancy, and not due to negative signal from the
> gestation itself.

You plead for an open license to shoot anything in the woods that moves. There has been no statement made in your theoretical assumptions that provides structure to rationality in your exercise of theory for a shotgun attack on a low or falling progesterone.

There is an interface between uncertainty and functional certainty in regard to absolute numbers and rate of change plotted against the time line since conception with serum progesterone. The probability of beneficial value of supplemental value drops like a rock as time extends from verification of the pregnant state. You have been mute on these numbers and a reasonable cut-off, including duration of pregnancy.

The issue of targeted use of supplementary progesterone beginning 2-3 days post luteal surge might well prove to be of value, among other options, in managing corpus luteal dysfunction, abnormal progesterone receptors or abnormally low density of PR, all on the maternal side. You have not shared the existence of divided opinion over the most effective options to deal with such entities beyond your admittedly non-specicific and usually failed efforts with progesterone supplementation at high tangible and intangible total cost.

--
Zach Newton
Z. B. Newton, III, M.D.
Atlanta/Gyn




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