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Re: Gail Model 7.4 / 47.5From: Efrain Ramirez (eramirez@icepr.com)Sat Apr 29 14:44:29 2000
Clinical development of estrogen modulators for breast cancer chemoprevention in premenopausal vs. postmenopausal women. [Record Supplied By Publisher] J Cell Biochem 2000;77(S34):103-114 (ISSN: 0730-2312) Lawrence JA; Malpas PB; Sigman CC; Kelloff GJ [Find other articles with these Authors] Chemoprevention Branch, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. Tamoxifen has proven to be beneficial in the chemoprevention of breast cancer in women at increased risk for the disease. Other compounds that mediate the estrogen pathway remain to be tested for clinical efficacy. The mechanism of action, efficacy, and dose response of the estrogen modulators is determined by the hormonal milieu of the host which should be considered in the early clinical trials for dose range finding studies and surrogate endpoint biomarker (SEB) evaluation. This review presents the hormonal effects to consider in the clinical testing of an agent in premenopausal vs. postmenopausal cohorts. Recommended SEBs that may be evaluated in Phase I/II clinical trials of estrogen modulators for breast cancer chemoprevention are presented. J. Cell. Biochem. Suppl. 34:103-114, 2000. Copyright 2000 Wiley-Liss, Inc. Language: English
That - or very close follow up - I ran your nubers in my calculator -
same results. At Fri, 28 Apr 2000, Karen Lee wrote:
>
-- "The things you learn after you know everything are the important ones"
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