Amenorrhea

From: George M. Grunert (ggrunert@houston.rr.com)
Sun Mar 5 20:01:33 2000


There is evidence that DepoProvera causes decreased bone mineral density in adolescents and young women who are actively laying down bone (Cromer et al: J Pediatrics 1996 129:671 and Scholes et al: Obstet Gynecol 1999 93:233). Looking at women over 35, no significant difference was observed (Bahamondes et al: Fertil Steril 1999 71:849). Prior use apparently has no significant effect at menopause (Orr-Walker et al: Clin Endocrinol (Oxf) 1998 49:615). There appears to be a significant chemical and radiological effect in young women (under 35), but this may be of limited clinical importance since there is only a single report of a tibial stress fracture in a woman on DepoProvera (Harkins et al: J Reprod Med 1999 44:309).

-----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net]On Behalf Of Paul Prior MD Sent: Sunday, March 05, 2000 12:07 PM To: Multiple recipients of list OB-GYN-L Subject: Re: amenorrhea

On Sun, 5 Mar 2000 10:20:58 -0600, "George M. Grunert, M.D." <grunert@ivfhouston.com> wrote:

>If they're on BCPs or DepoProvera, they're adequately protected from
>osteoporosis. Those on meds which induce amenorrhea (such as phenothiazines

Would be interested in further comments regarding your statement that DepoProvera protects against osteoporosis.





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