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Re: tocolysisFrom: ainsron@msn.comWed Feb 16 23:31:18 2000
At Wed, 16 Feb 2000, Efrain Ramirez wrote: > >Intersting -- where Ron? Never used it. South Med J 1998 Nov;91(11):1028-32 A comparative study of ketorolac (Toradol) and magnesium sulfate for arrest of preterm labor. Schorr SJ, Ascarelli MH, Rust OA, Ross EL, Calfee EL, Perry KG Jr, Morrison JC Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson 39216-4505, USA. BACKGROUND: We evaluated the efficacy and safety of ketorolac (Toradol). METHODS: In this prospective trial, 88 women in confirmed preterm labor at < or 2 weeks' gestation were randomized to receive magnesium sulfate given as an initial 6 g intravenous bolus followed by continuous infusion therapy (2 to 6 g/hr) or intramuscularly administered ketorolac (60 mg loading dose) followed by 30 mg every 6 hours for a maximum of 24 hours. RESULTS: The study groups were similar with respect to age, parity, cervical status, and gestational age on admission. Ketorolac was more rapid (2.71 hr+/-2.16) in the arrest of preterm labor than was magnesium sulfate (6.22 hr+/-5.65). No patient required discontinuance of either drug due to adverse effects. There was no difference in the incidence of neonatal complications between the two groups. CONCLUSION: In gestations with preterm labor at <32 weeks, ketorolac appears to be an appropriate first-line tocolytic agent.
-- Ronald E. Ainsworth, MD
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