Re: falgyl reaction for trich

From: ainsron@msn.com
Mon Feb 7 21:33:47 2000


I had a patient last year with a history of anaphylaxis with Flagyl who had been infested with trichomonas for five years and had seen several docs. After researching it, I tried everything that has been suggested. Nothing worked. I even considered bringing her into the hospital to pretreat with benadryl and steroids, then hitting her with IV flagyl. Fortunately, she also had severe dysplasia on her pap and biopsies and wanted a hysterectomy for treatment. After the TVH, NO MORE TRICH!! I assume that means it was in the endocervical glands and once the glands were gone, so was the bug. Certainly a hysterectomy for treatment of trich is a bit drastic, but this lady had been infested for five years when I first saw her, talk about grateful, she was the epitomy of grateful.

>>pt had allergic reaction(hives) to flagyl.
>>pt has trich.
>>any alternative suggestions?
>>have not found any good infor from cdc or journals.
>>thanks
>>guy
>>
>>--
>>guy
>>
>--
>
>I have uses Betadine douches daily for several days for some patients
>who do not tolerate Flagy.
>
>Of Historical Note.
>Before Flagyl, the following was offered: NEJM, Sept. 26, 1935; page
>633.
>
>The vagina is scrubbed with cotton saturated in half strength tincture
>of green soap and left for 5 minutes. The soap is next thoroughly
>washed out with and irrigation of hot mercury oxycyanide solution
>1:3000. A speculum is introduced, the vaginal wall dried with cotton
>gauz, and 2 drams of 1% picric acid in glycerine poured in. The vagina
>is then packed with gauze bandage and the patient is directed to remove
>the packing 24 hours later. For the first 2 or 3 weeks the treatment
>should be given every second day, but after that they may be spaced
>farther and farther apart. In addition to these treatments the patient
>is advised to take a slow 2 quart douche of hot 1:3000 mercury oxycanide
>solution each night before retiring except on those days when she has
>been treated. The douches are continued through the menstrusl periods.
>
>--
>I would not use mercury oxycanide solution today.
>
>--
>John Hellriegel, MD, PhD
>

--
Ronald E. Ainsworth, MD




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