Re: Mitochondrial M5 antibodies

From: Mark G. Newman (mgnewman@flash.net)
Sun Jan 30 13:27:25 2000


Danny:

There is an article on M5 as an alternative marker for antiphospholipid syndrome:

Anti-mitochondrial M5 type antibody represents one of the serological markers for anti-phospholipid syndrome distinct from anti-cardiolipin and anti-beta2-glycoprotein I antibodies. (La Rosa L; Clin Exp Immunol, 1998 Apr)

I am unaware of any literature linking M5 antibodies to preeclampsia. Let me know if you find anything else; mito antibodies and genetics is an interest of mine

Mark Newman, MD Perinatal Associates of Texas

>----- Original Message -----
From: Danny Tucker <danny@womens-health.co.uk> To: Multiple recipients of list OB-GYN-L <ob-gyn-l@forum.obgyn.net> Sent: Sunday, January 30, 2000 2:10 PM Subject: Mitochondrial M5 antibodies

> Last week I saw a patient for pre-pregnancy counselling who has had 3
> previous pregnancies complicated by very severe, early-onset
> eclampsia/preeclampsia requiring admission to ICU on 2 of these occasions.
> Only positive finding is mitochondrial M5 antibodies.
>
> Does anyone have any sources for more information on this, or the possible
> protection that aspirin/heparin might afford. At present she has been
> strongly advised against further pregnancy.
>
> Thanks,
>
> Danny.
>
> --
> Danny Tucker MRCOG
> Specialist Registrar, Sheffield, UK.
>
> http://www.womens-health.co.uk
>





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