Re: GBS and HRT--Breast ca

From: J. Hellriegel (jhellrie@pce.net)
Sat Jan 29 21:33:27 2000


At Sat, 29 Jan 2000, Harnath Holmes wrote: >
>Right now I can't even get PCN. The hospital has 3 vials left and their
>supplier won't ship any until the fall. Initially I liked the "risk factor
>based" way of antibiotic prophylaxsis. Fewr women were treated but the
>scenarios of a past GBS + culture or unk GBS culture were eliminated. I
>have had babies die of GBS so I know its real. However most of the MFM
>groups went right to screening cultures and abandoned the risk factor
>approach, therefore I changed to the screening. I have been seeing a lot
>more patients turn up positive and therefore am treating a lot more women in
>labor. But I am not sure we can take a 'step back' to risk factor triage.
>
>On the HRT note, Most of their discussion seemed to defend possible bias.
>Many of their confidence intervals contained 1.0 which I thought ment they
>weren't very confident. In all those women studied they could only find 33
>for one conclusion? Hard to base changing everyone's HRT on 33 women.
>
--
Agree with above.  Does raise questions.  Also note that the 11 women on
progesterone alone had a relative rate of 0.8.

Had lots of calls from patients who left a message that they were terminating their HRT because of the news reports.

--
>Yes I get lots of questions about these "news media" studies.  It is very
>hard to convince someone of the other benefits after Oprah or Dan Rather has
>told them that the HRT will give you breast cancer.  Does anyone think the
>new micronized progesterone will be different or how about the new
>norgestimate (ortho prefest) or the other new one (Femhrt) will be
>different?  Is it really just provera or all progestins?
>
>Har Holmes, MD
>FACOG
>Little Falls, MN
>
>PS.  No central monitors here either Jane.

--
John Hellriegel




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