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Re: OIFrom: Allan Fisher (fisheraj@umdnj.edu)Thu Jan 20 12:35:30 2000
Well, as you may be very aware, OI come in many types. Basically there are severe forms including the lethal types and less severe types. It can be detected in utero on CVS material or fetal skin but not well on amniocytes (you need fibroblasts). Therefore one would need to do this at an early stage of the pregnancy for two reasons. Beyer's lab, in Washington state, is the only lab that is reliable (in the States) that performs this assay and it takes many weeks to get an answer back. Secondly, it is important that you have the true diagnosis of the proband first before you start placing needles into the fetal compartment. The less severe types do not typically fracture in utero or during the birthing process. My last patient with OI (type III) delivered via section due to a prolonged deceleration but was in the process of delivering vaginally. Good luck. Consult your local Medical Geneticist for more diagnostic information and for the proband's true diagnosis.
-- Allan J. Fisher, MD, FACOG, FACMG Division of Maternal-Fetal Medicine 254 Easton Ave, MOB 4th Floor New Brunswick, NJ 08903-0591 T- (732) 745-8549 F- (732) 249-5729 I - fisheraj@UMDNJ.edu
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