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ASA/Itching/PregnancyFrom: Efrain Ramirez (eramirez@icepr.com)Thu Jan 6 07:49:14 2000
Doing some reading because... Antihistamines versus aspirin for itching in late pregnancy Young GL, Jewell MD ABSTRACT A substantive amendment to this systematic review was last made on 30 June 1994. Cochrane reviews are regularly checked and updated if necessary. Background and objectives: While not common, itching in pregnancy (not due to liver disease) can be distressing. The objective of this review was to assess the effects of treatment for itching in late pregnancy. Search strategy: We searched the Cochrane Pregnancy and Childbirth Group trials register. In addition, the Cochrane Controlled Trials Register (CENTRAL/CCTR) was searched. Date of last search: April 1999. Selection criteria: Randomised trials of treatments for itching in women in late pregnancy with normal liver function. Data collection and analysis: Trial quality was assessed and data were extracted independently by two reviewers. Main results: One study of 38 women was included. This was a small crossover trial, using alternate allocation. The trial compared a histamine, chlorpheniramine, with aspirin. Aspirin was more effective than chlorpheniramine in relieving itching (odds ratio 2.39, 95% confidence interval 1.25 to 4.57). However chlorpheniramine was more effective than aspirin when a rash was present. Reviewers' conclusions: Aspirin appears to be more effective than chlorpheniramine for relief of itching in pregnancy when no rash is present. If there is a rash, chlorpheniramine may be more effective. Can't find articles -- none --zip. Anyone with better luck?
-- "The things you learn after you know everything are the important ones"
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