WOMENS-HEALTH Messages for July, 1999: Use of Proluton Depot for prevention of premature contractions

Use of Proluton Depot for prevention of premature contractions

From: Nandita (anonymous@obgyn.net)
Wed, 28 Jul 1999 02:11:34 -0500 (CDT)

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I have PCOD (Poly Cystic Ovarian Disease). I found out in October '98 and was undergoing treatment for the same. I concieved in February '99 in a strictly monitored menstrual cycle. I was being given injections of Metrodin earlier and later was switched onto Recagon.

After conception I was taking weekly doses of Profesi IU 2000 weekly and Utrogestron twice daily (100mg). This was the first 14 weeks after conception.

Approximately 16 weeks from the last period date, I had a bit of spotting and was adviced bed rest along with weekly injections of Proluton Depot. After 3 weeks I was able to go back to work.

After another 2 weeks, I had painful lower abdominal cramps and was hospitalised for 48 hours with "Premature Contractions". Since then I've been adviced complete bedrest and weekly doses of Proluton Depot and twice daily Duvadilan Retard tablets.

I had a minor fungal infection in the uterus which was treated with a Tab Augentin taken 3 times a day for 10 days. This was done after the day I had the contractions. The infection was indicated in a test done a week earlier and repeated after the contractions. All other physiological aspects (cervical length, state of Internal OS and External OS and the growth and state of the foetus) are normal.

My query is - I have heard of conflicting views about the continued advantage of the use of Proluton Depot under the given circumstances. Since it is a hormone injection and this hormone is being produced by the placenta anyway, what is the purpose of giving this injection? Has there been any medical research or study conducted on the advantages of using it for such treatment (or contrary to the fact)? Are there any published papers on this?

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