WOMENS-HEALTH Messages for March, 1998: Re: ?Flagyl related to my miscarriage?

Re: ?Flagyl related to my miscarriage?

From: Harvey S. Marchbein, M.D. (anonymous@obgyn.net)
Tue, 3 Mar 1998 18:58:44 -0600 (CST)

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In reply to: Jennifer: "?Flagyl related to my miscarriage?"

At Tue, 3 Mar 1998, Jennifer wrote: >
>My OB diagnosed me with BV while I was 8 weeks pregnant. She started me
>on Flagyl 250 tid x10 days.
>During this time I changed doctors. My new doc told me to stop taking
>flagyl immediately. I soon found out that it is contraindicated in
>first trimester pregnancy. I was on this drug for 9 days and miscarried
>2 wks later. Ive done some reading, Ive found out that its method of
>action is .."to disrupt DNA synthesis to all suseptible organisms"
>(DAVIS'S DRUG HANDBOOK).It also says that it crosses the placenta at the
>same rate as maternal plasma, which is at 80%. After reading this I
>cant help but feel that this carcinoginic drug could have harmed my
>baby, during its most fragile developmental stage.
>I am curious to know if there could be a connection between
>FLAGYL/MISCARRIAGE. Has this ever been studied?
>Thank you in advance,
>Jennifer Lynne Kelly
>302 Mill Pond Rd.
>Roswell, Ga. 30076
>(770)650-0241
>
>pwilli5631@aol.com
>
>--
>Jennifer Kelly
>

It was originally felt that Flagyl was contraindicated in pregnancy but from usage for many reasons in pregnant patients who had to take Flagyl for a variety of reasons, this has not borne up under scientific scrutiny.

As a general point, with most medications, it is felt that treatment in the second trimester reduces fetal exposure during organogenesis.

--
Harvey S. Marchbein, M.D. FACOG
OBGYN.net U.S. Representative, New York
Great Neck, New York
http://www.obgyn.net/states/bios/marchbein.htm
http://www.obgyn.net/women/advisors/harveym.htm

**Note:  Opinions expressed here are for educational purposes only
and, as such, do not constitute a physician-patient relationship.
This information is not intended to supplant the need for you to
consult with your physician prior to choosing therapeutic options
and/or interventions.

**Private emails cannot be entertained due to time constraints,
consequently no private emails will receive a response.

**Thank you for your understanding ;-)

Next message: Lin: "New Estrogen Pills that doesn't increase Breast Cancer Risk?"
Previous message: Harvey S. Marchbein, M.D.: "Re: cytoscopy and hydrodistention"
In reply to: Jennifer: "?Flagyl related to my miscarriage?"

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