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Re: progesterone

From: Laurie (anonymous@obgyn.net)
Wed, 28 May 1997 05:28:12 -0500 (CDT)


At Tue, 27 May 1997, Sara wrote: >
>My doctor has recommended progesterone shots every three months to
>correct my irregular periods and excessive bleedling. Can you please
>tell me what other forms progesterone comes in, how effective the
>various forms are and the side effects that it can produce. I was told
>I would not have periods with the shots.
>Thank you,
>
>--
>Sara Fernandez
>

Based on the dosing schedule, it sounds like the shot your doctor is recommending is Depo-Provera. This is a synthetic form of progesterone that suppresses ovulation and provides very effective contraception for 3+ months. The most troublesome side effects are (1) irregular bleeding, although approximately half of women getting the shot will have no bleeding at all after their second injection; (2) weight gain that averages 5 pounds at the end of one year and 7 pounds at the end of two years; and (3)irregular bleeding or lack of bleeding that can persist for 6-8 months following the last injection.

The medication in Depo-Provera is medroxyprogesterone acetate, and it's also available in an oral form in various strengths.

"Natural" progesterone is broken down and rendered inactive when taken orally, so it has to be treated in some way to make sure it's not inactivated. Micronized oral and sublingual (under-the-tongue) progesterone is not widely available in the U.S. See the posts on natural progesterone cream for information about that product.

--
Laurie Lovely, MD
RE fellow, UNC-Chapel Hill



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