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Re: ENDOMETRIOSIS: Sampson's Theory - infoFrom: Hope Waltman (anonymous@obgyn.net)Sun, 26 Apr 2009 10:46:08 -0500 (CDT)
ENDOMETRIOSIS - Sampson's Theory additional information: http://www.obgyn.net/hysteroscopy/hysteroscopy.asp?page=/hysteroscopy/articles/liu_endo_causes Sampson’s Theory This theory was proposed by Dr. John Sampson of Boston in the 1920’s. His theory that menstrual blood refluxed through the fallopian tubes and was deposited and grew on the pelvic peritoneum and pelvic organs remains popular, but the initial attachment of single or multiple endometrial cells on the peritoneal surface has not been demonstrated. Additionally, the time-related geographic spread of endometriosis throughout the pelvis that would be predicted to occur with repeated seeding of the peritoneum by refluxed endometrium has not been demonstrated. The fact that 90% of women have retrograde flow but only 15 % of women develop endometriosis further repudiate the validity of the theory. This theory of origin also implies that older age groups of patients with endometriosis have more disease than younger age group and a high and progressively increasing rate of recurrence after complete surgical resection. The literature, however, as well as our own experience has shown that the actual rate of persistent or recurrent disease is surprisingly low after aggressive conservative surgical excision at laparoscopy or laparotomy, and the rate of recurrent or persistent disease does not appear to increase with the passage of time following excision. Because of these deficits, Sampson’s theory is losing favor to more modern concepts. http://www.obgyn.net/pelvic-pain/pelvic-pain.asp?page=articles/fluids_in_endo http://www.obgyn.net/women/women.asp?page=/women/articles/endo_dah Endometriosis is a common and often frustrating gynecologic condition that can cause a number of disturbing symptoms. Although the true incidence is unknown, many experts believe that between 3% and 10% of women have this condition. The term endometriosis (say "in-doe-meet-ree-oh-sis") was coined in 1927 by Dr. John Sampson, who theorized that this condition is caused by menstrual blood "backflowing" through the fallopian tubes and into the abdominal cavity. For example, just as sperm can travel through the uterus and out the tubes, so can tiny particles of blood from a menstrual period. These particles "implant" on the organs around the fallopian tubes, including the uterus, ovaries, ureters (the tubes coming from the kidney to the bladder), top of the vagina (called the cul-de-sac), and perhaps intestines. Although there are other theories to explain endometriosis that occurs in areas of the body far away from the female organs, Sampson's theory is the best explanation thus far of how endometriosis occurs. As the implants grow and respond to hormonal stimulation, they can cause symptoms. Interestingly, endometriosis has been diagnosed in unusual locations like the knees, thumbs, thigh, vulva, lungs and liver, and has even been diagnosed in men receiving estrogen therapy. Endometriosis forum group: http://www.endometriosiszone.org/ Best Regards, Hope Waltman, WHF Moderator http://www.hopeforfibroids.org
At Sat, 25 Apr 2009, Scarlett wrote:
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