Re: Soft markers for genetic problems
From: Philippe Coquel (philippe.coquel@wanadoo.fr)
Mon Oct 13 13:08:30 2003
It's better to use Likelihood ratio than PPV or NPV to eliminate the problem
of the prevalence.++++
The Bayes's Theorem is the best tool.
The best LR is nucal translucency in 1 st trimester and nasal bones and
nuchal fold in the second trimester.
But it seems that soft markers have a little signification after the main
filter of 12 wa nucal translucency measurement.
Ph coquel
>----- Original Message -----
From: "Terry J. DuBose" <duboseterryj@uams.edu>
To: "Multiple recipients of list ULTRASOUND" <ultrasound@dns.obgyn.net>
Sent: Monday, October 13, 2003 6:05 PM
Subject: Re: Soft markers for genetic problems
> Yes, and probably the NT is the better of the two.
> Thanks, Terry
>
> ultrasound@obgyn.net writes:
> >I am pretty sure that nuchal translucency and nuchal fold have the
highest
> >likelihood ratio.
> >
> >Allen
>> >----- Original Message -----
> >From: "Terry J. DuBose" <duboseterryj@uams.edu>
> >To: "Multiple recipients of list ULTRASOUND" <ultrasound@dns.obgyn.net>
> >Sent: Monday, October 13, 2003 7:44 AM
> >Subject: Re: Soft markers for genetic problems
> >
> >> Ok, Ok,... I am primarily interested in the relative benefit (ranking)
of
> >the various soft markers, higher to lower... it is an academic question,
not
> >a clinical one. Thanks, Terry
> >>
> >> ultrasound@obgyn.net writes:
> >> >What matters is not the PPV, but also the confidence interval (is a RR
of
> >3
> >> >significant ? is 1/139 different from 1/289 ?)
> >> >
> >> >-----Original Message-----
> >> >From: ultrasound@obgyn.net [mailto:ultrasound@obgyn.net] On Behalf Of
> >Terry
> >> >J. DuBose
> >> >Sent: Monday, October 13, 2003 8:46 AM
> >> >To: Multiple recipients of list ULTRASOUND
> >> >Subject: Soft markers for genetic problems
> >> >
> >> >Does anyone here have a recent reference that gives the accuracy
> >(positive
> >> >predictive value) of "soft markers" in obstetrical sonography?
> >Particularly
> >> >for those below and/or others? thanks Terry
> >> >
> >> >Long bone length
> >> >Nuchal translucency
> >> >Ear length
> >> >Bowel
> >> >Pelvic bone width
> >> >Heart/intracardiac foci
> >> >Toes/sandal foot
> >> > hands/missing middle metacarpal fifth digit
> >> >Pylectasis
> >> >3 vessel cord
> >> >Choroid plexus cysts
> >> >Nasal bones
> >> >
> >> >Terry J. DuBose, M.S., RDMS, FSDMS, FAIUM
> >> >Assistant Professor & Director, Diagnostic Medical Sonography Program
> >> >University of Arkansas for Medical Sciences, CHRP
> >> >4301 West Markham St. Mail Slot #563
> >> >Little Rock, Arkansas, 72205 USA
> >> >501-686-6510
> >> >DuBoseTerryJ@UAMS.edu
> >> >http://www.io.com/~dubose/
> >> >http://www.uams.edu/chrp/dms/default.asp
> >> >http://www.obgyn.net/us/panel/panel.htm
> >> >
> >>
> >> Terry J. DuBose, M.S., RDMS, FSDMS, FAIUM
> >> Assistant Professor & Director, Diagnostic Medical Sonography Program
> >> University of Arkansas for Medical Sciences, CHRP
> >> 4301 West Markham St. Mail Slot #563
> >> Little Rock, Arkansas, 72205 USA
> >> 501-686-6510
> >> DuBoseTerryJ@UAMS.edu
> >> http://www.io.com/~dubose/
> >> http://www.uams.edu/chrp/dms/default.asp
> >> http://www.obgyn.net/us/panel/panel.htm
> >>
> >
>
> Terry J. DuBose, M.S., RDMS, FSDMS, FAIUM
> Assistant Professor & Director, Diagnostic Medical Sonography Program
> University of Arkansas for Medical Sciences, CHRP
> 4301 West Markham St. Mail Slot #563
> Little Rock, Arkansas, 72205 USA
> 501-686-6510
> DuBoseTerryJ@UAMS.edu
> http://www.io.com/~dubose/
> http://www.uams.edu/chrp/dms/default.asp
> http://www.obgyn.net/us/panel/panel.htm
>
