PCOS Messages for June, 2001: Re: My Sleep Study -- Sleep Disorders and Hormones

Re: My Sleep Study -- Sleep Disorders and Hormones

From: LF (anonymous@obgyn.net)
Thu, 28 Jun 2001 11:45:12 -0500 (CDT)

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Susan and Jen (and anyone else interested in this), That must be the same report my ENT was thinking of, but he didn't give a reference. Did you make note of any references? So far, this is the most official report I have found on the Internet:

Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, Kales A, Chrousos GP., J Clin Endocrinol Metab. 2000 Mar;85(3):1331-3 (Summary here: http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=9141509) This study was done on men, but the IR association is still relevant.

I also found this statement that is quite easy to understand:

Question: What is the relationship between stress, cortisol, and central fat accumulation?

Doctors' answer: Stress increases cortisol levels, and higher levels of cortisol increase insulin resistance. We can see the relationship between cortisol and insulin resistance in sleep apnea. Sleep deficits increase cortisol levels which increase insulin resistance. In turn, insulin resistance may worsen sleep apnea.

(http://www.inciid.org/pcos/panel2-060100.html)

How's that for a vicious circle? The stress from apnea increases IR, and IR makes the sleep apnea worse. Many sleep apnea sufferers need to lose weight, but the IR makes it difficult.

I'm going to attack it from both ends: Get treatment for the sleep apnea and use glucophage to help with the IR. (Plus try to exercise more regularly to help with everything!)

--LF-- ==========

At Wed, 27 Jun 2001, Susan C. wrote: >
>Something kind of interesting to add to that - I was watching the news
>yesterday and they had a report stating that recent studies have shown
>that not sleeping well can lower your insulin sensitivity. I know a lot
>of the women here have talked about not having the greatest sleep
>patterns, so I wonder if that is just another aggravating little plus
>for us!
>Susan C.
>
>At Wed, 27 Jun 2001, Jen wrote:
>>
>>At Mon, 25 Jun 2001, LF wrote:
>>>
>>>Anyway, I mentioned my recent diagnosis of PCOS, its ties to insulin
>>>resistance, and my prescrip for glucophage. He told me that recent
>>>studies show that sleep apnea can throw off your endocrine system! He
>>>said when I'm struggling at night, my body is running off adrenaline,
>>>which is a hormone, and it throws off the mix.
>>>
>>I have sleep apnea, and my husband noticed when I was on "the pill" that
>>it seemed better. I can't help but wonder which causes which. Men tend
>>to get sleep apnea more, so I'm wondering if it's the testosterone? And
>>then, the sleep apnea makes the PCOS worse, and it's a vicious cycle!
>>Anyway, send me any links you find, too.
>>
>>You know what's really interesting? There are many women with
>>fibromyalgia who have PCOS, and fibromyalgia has been linked to sleep
>>disorders. Just makes you wonder. My father had fibro, and I think my
>>mother had PCOS. I was doomed from the start!
>>
>>--
>>jen
>>

Next message: Tamara: "Looking for a good RE in Oklahome for my sister."
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In reply to: Susan: "Re: My Sleep Study -- Sleep Disorders and Hormones"
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