Re: Rhogam

From: YankowitzJ@obgyn-po.obgyn.uiowa.edu
Mon Jun 30 08:53:13 1997


Denise,

>Rh neg. NSVD x 2 with rhogam after del. TAB @ 20 wks
>without rhogam. Presents for first prenatal visit. No dates. FH is 36 cm.
>UTZ today 34w5d. Antibody screen neg.

>Would you give rhogam today? Why or why not?

Absolutely would give rhogam. Current standard of care is to give at 28 weeks. This reduces the sensitization between then and delivery. While there have been a couple papers arguing that this is not cost effective it is still what we do in the US. The patient is lucky to have not become sensitized after the TAB and up until now. I wouldn't compound the situation by skipping the rhogam.

>She delivers 4 weeks later. NSVD. Baby is Rh positive.
>If you gave rhogam at the initial visit, would you give it again?

Yes I would give again. No risk from the rhogam that I know of (Europe had a few cases of Hep C but their regulation of production is different than in US- Lancet article). I would give despite my answer below....

How long does rhogam work?

Probably about 12-14 weeks as shown by F Witter many years ago and by others more recently I think.

Jerry Yankowitz, MD Maternal Fetal Medicine and Clinical Genetics Univ of Iowa Hospitals and Clinics





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