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a triple translocationFrom: Allen Gardner (allen.gardner@utoronto.ca)Sun Sep 8 08:45:33 1996
Has anyone had anything similar? A 40 yr. old woman studied b/o infertility. Husband normal, but she has t(X;3;11)(p11.4;q12;q12). She is adapted i.e. no family history. THE HISTORY IS FROM HER GYN. Regular periods until hyperprolactinemic (no adenoma) and reverted to normal with parlodal. Since 1993 she's had 9 cycles monitored each requiring increasing doses of clomid and pergonal with little ovulatory effect. Finally on a high dose of fertinorm she produced 3 eggs. 2 were retrieved, only 1 was fertilized and she probably had an early SA (chemical pregnancy). She seems to have a positive hormone response indicative of ovulation with her natural cycles but never any pregnancy. The picture would seem to be one of low numbers of viable eggs. Presumably the translocation is to blame. Agree?? Any thoughts would be appreciated. If the history seems scanty it's because the gyn and myself are geographically separated. Thanks. Allen.
-- Allen Gardner MD Genetics Oshawa General Hospital Oshawa, Ontario, Canada 905 433 2733
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