Re: Amenorrhea

From: Mats Bergstrom (matsb@cor.sos.sll.se)
Wed Sep 4 13:51:44 1996


On Wed, 4 Sep 1996 DoctorJoe@aol.com wrote:

> the estrogen. What we're saying is that the physician shouldn't feel guilty
> about withholding estrogen (if you think it's dangerous in this situation) if
> the patient won't even stop smoking.

But is it 'dangerous' in the sense that OC's and smoking are *multiplicatively* enhancing risks (of coronary heart disease and possibly stroke - note that smoking does NOT increase the risk for tromboembolic disease)? If the risks are only additive, then the rise in absolute risk is very small from OC's. And this reasoning is only for OC's. Regarding estrogen replacement therapy (E2 etc), since it might lower the risks for CHD and stroke, perhaps there is a stronger indication for it in smokers? These questions are not easily answered at the present level of knowledge.

--
Mats Bergstrom, MD
Ob Gyn
South Hospital
Stockholm




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