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Re: LPD and Progesterone From: Danny Tucker (danny.tucker@dial.pipex.com) Sat Aug 31 19:11:42 1996 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Douglas Krell: "Re: true story related to politics discussion" Previous message: Suddoc@aol.com: "Re: Ob/gyn software" In reply to: George M. Grunert: "LPD and Progesterone" In article <2.2.32.19960831152206.006df6f8@icsi.net>, "George M. Grunert" <grunert@ICSI.Net> writes >LPD is a recognized cause for recurrent pregnancy loss, even if a bit over >diagnosed and over treated. The first line of treatment in a patient with >LPD (2 consecutive out-of-phase late luteal endometrial biopsies) who has >low serum progesterone levels at the time of biopsy is with progesterone. >Response should be documented by demonstration of elevation of the serum >progesterone level as well as correction of the LPD on biopsy. In patients >with LPD and a normal progesterone, or in whom the LPD does not correct with >normalization of the progesterone level, correction can sometimes be >successful by inducing progesterone receptors using clomiphene or gonadotropins. George, I am interested in your comments here. Could you please quote some studies which support the use of progesterone in recurrent miscarriage? I have searched for this, as I learn from the internet that its use is quite widespread in the US, certainly moreso than the UK. From what I can see the use of progesterone for this indication is not evidence- based. The studies listed below find no significant improvement in pregnancy success rate with progesterone supplementation. Of course I understand its use in IVF cycles is well proven. Regards, Danny. ---------------------------------------------- Dr Danny Tucker ---------------------------------------------- Obstetrics & Gynaecology -- ---------------------------------------------- Nottingham, UK danny.tucker@dial.pipex.com ---------------------------------------------- Goldzieher JW. Double-blind trial of a progestin in habitual abortion. ---------------------------------------------- Journal of American Medical Assoc. 1964;168:651-4 ---------------------------------------------- Klopper A. Hormones in recurrent abortion. J Obstet Gynaecol Br Commonw 1965;72:1022-8 Govaerts-Videtzky M et al. A double-blind study of progestogen treatment in spontaneous abortion. J Obstet Gynaecol Br Commonw 1965;73:1034 Shearman P. Double-blind study of effect of 17-OH Progesterone caproate on abortion rate. BMJ 1963;292-5 (Feb 2) Progestagens in threatened abortions. Tognoni G et al. Lancet 1980;1242- 3 (Dec 6) Reijnders FJ et al. Endocrine effects of 17 alpha-hydroxyprogesterone caproate during early pregnancy: a double blind clinical trial. Br J Obs Gyn 1988;95:462-8 The role of luteal phase support in infertility treatment: a meta- analysis of randomised trials. Fertility & Sterility. 61 (6):1068-76 (June 1994) Next message: Douglas Krell: "Re: true story related to politics discussion" Previous message: Suddoc@aol.com: "Re: Ob/gyn software" In reply to: George M. Grunert: "LPD and Progesterone"

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