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cord blood, cord phFrom: Terrence.Jones@ncal.kaiperm.orgWed Aug 28 15:20:29 1996
Regarding cord blood for stem cell harvesting. Apart from the issue of creating a bank of potentially safer transplant tissue for an ever-increasing number of potential recipients, has anyone looked at cost analysis comparison for potentially 'high-risk' individuals? (Jeez, that question sure uses 'potent' alot, must've been the hike thru the hoodoos at Bryce Canyon!) For instance: in a pregnant pt. with fam hx of myeloproliferative disorder, or personal hx of lymphoproliferative disorder, or breast Ca; might cord blood banking (Lancet 7/95, 346:214-9, Wagner) be a more cost-effective source of stem cells following high dose RT than allogeneic peripheral stem cells from filgrastim stimulated donors over 3-4 aphareses (Blood 3/95, 85:1659-65, K:orbling)? Might there be individuals at sufficiently high risk of recurrence that harvesting at delivery offers both a safer, AND cheaper management option? Do people with banking experience (with and without gelatin clearance of RBC's), have data regarding long-term cryopreservation and viability? Regarding cord pH and base excess to distinguish metabolic from resp. acidosis in assigning potential causes to HIE (hypoxic encephalopathy) - Has anyone any experience with MRI and assigning the "timing" of hypoxic damage. Also, if the cord pH doesn't fit the apgar, consider a kleihauer. Terry Jones Kaiser SF Ob/Gyn
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