Re: Advanced Paternal Age

From: ATB28@aol.com
Sun Aug 11 18:27:52 1996


In a message dated 96-08-11 08:27:53 EDT, you write:

<< What constitutes "advanced paternal age"?

Do you have a recommendation for prenatal diagnosis based on paternal age? >>

Most would consider a paternal age of 50 years "advanced" and, at least in our practice, we advocate a targeted ultrasound scan in all such instances ... due to the increased risk of skeletal dysplasia (e.g., achondroplasia).

Furthermore, we (somewhat arbitrarily) double the maternal age risk for fetal chromosome anomalies. If the father is 65 and the mother is 18 (those in Las Vegas will appreciate this), for example, the new maternally derived risk for chromosome abnormalities would likely not exceed most thresholds (35 year's risk) so prenatal diagnosis by amnio/CVS would not be indicated. On the other hand, if the mother is 32, the doubled risk would likely exceed most accepted thresholds for offering testing this woman would be a candidate for invasive prenatal diagnosis.

Thoughts from elsewhere....?

Allan T. Bombard, MD Director, Division of Reproductive Genetics Department of Obstetrics & Gynecology Albert Einstein College of Medicine and the Montefiore Medical Center 1695 Eastchester Road; Suite 301 Bronx, NY 10461





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