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Re: Citomegalovirus IgM positiveFrom: Bert Gold (bgold@itsa.ucsf.EDU)Mon Aug 5 23:42:58 1996
Donner et al. (Obstet. Gynecol. 82, 481-486 (1993)) have suggested that termination before antenatal detection is not indicated as only 1/20 fetuses will develop sequelae. Antenatal detection can be accomplished by amniotic fluid culture (Gold Standard) or you may try CMV DNA PCR which is not as well correlated with sequelae. No test can discriminate, when the ultrasound is normal, between the 90% of fetuses which develop normally and the 10% of fetuses which suffer sequelae. Donner found that antenatal detection using cuture had an 81% sensitivity with only one false negative. CMV is a herpesvirus and Bernard Roizman at Chicago has expressed to me that it may never go away, but remain in a reservoir (like HSV), only this time in a leukocyte rather than a neuronal population.
-- Bert Gold, Ph.D. "Seeing much, Suffering much, University of California, San Francisco and studying much, School of Medicine These are the three pillars Program in Medical Genetics of learning." -- Benjamin Disraeli
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