Re: What's next-steroids after 34 w
From: Efrain Ramirez (eramirezt@coqui.net)
Wed Apr 30 17:54:37 2008
C/S on Monday - baby girl 3# 12 oz.. baby and mother doing well..
Thanks all for the input..
Ef
At Tue, 29 Apr 2008, art fougner, md wrote:
>
>So Ef ...
>
>Any Follow-up?
>
>Art
>
>At Tue, 29 Apr 2008, JD Stewart,MD wrote:
>>
>>Logic can prevail, if we allow...big studies/ Meta analyses showing a
>>smaller head circ and 5% less average body weight have a fatal flaw
>>inherent in the study populations in that they do not account for
>>factors we know have such an effect- namely smoking ( cited at an
>>average 8 ozs less at birth at term), maternal weight gain, drug abuse,
>>use, work patterns, history of preterm births ..etc. Some have even
>>included twins and anomalous babies.
>>
>>No long term growth deficits or developmental aberrations in all these
>>children of moms with asthma or allergies or CT disorders who have been
>>on large repeated doses of steroids have been shown in the last 40
>>years...
>>
>>Steroids work every day, just as they will continue to work until we are
>>buried. The problem is a statistical matter (nearly impossible to
>>gather enough data to show an p<.o5 improvement over a baseline 98-99%
>>survival without problems..) not a biochemical or physiologic process
>>that suddenly stops working on a magic date.
>>
>>Re: Should we dose/ redose at 34-35-even 36w? Ask yourself- What does it
>>hurt? How sure can any of us be about gestational dating? If the baby
>>does come "late preterm" and is that 1-2% with problems, who is going to
>>defend your "not recognizing her risk for delivering early and and
>>failing to offer steroids/progesterone/cerclage/smoking cessation/
>>aromatherapy SOONER?"
>>
>>Why tocolyse at 34-35-36 if doing so will not improve the outcome
>>(unless you give steroids...)?
>>
>>Questions for article below: Hospitalization/ off work/ tocolysis for
>>weeks has no economic cost?
>>
>>At Sat, 26 Apr 2008, Efrain Ramirez wrote:
>>>
>>> Neonates born after
>>>34 completed weeks of gestation rarely have mortality or major
>>>morbidity, but the financial costs remain significant ($7000 per case),
>>>and efforts to prevent delivery at this gestational age are probably
>>>indicated. Economic costs associated with PTB include the cost of
>>>initial hospitalisation, the cost of any chronic diseases resulting from
>>>the prematurity and social costs including loss of gainful employment by
>>>a family member taking care of the infant or child and loss of potential
>>>future earnings of the affected child.
>>
>> Antenatal steroids, if given to
>>>the mother at least 48 hours prior to a PTB, have shown significant
>>>reductions in RDS, IVH and NEC. Efforts to prevent, or avoid, PTB
>>>include the use of tocolytic agents which have been shown to prolong
>>>gestation for a minimum of 48 hours, or longer in some cases. The range
>>>of tocolytic agents used to delay or prevent PTB work through many
>>>different pathways, with varying degrees of success. Which tocolytic
>>>agent to use depends on many factors including underlying maternal
>>>status, gestational age of the fetus and documented efficacy of agent
>>>used.
>>>
>>>At Fri, 25 Apr 2008, Garry E. Siegel, M.D. wrote:
>>>>
>>>>Thanks for the input, Dan and Ef.
>>>>
>>>>Is there evidence to use steroids as you've suggested, or is it just
>>>>based on experience/obstetric horse sense?
>>>>
>>>>Isn't there a bit of a thought that steroids may have long term growth
>>>>consequences? In other words, there may be harm such that one shouldn't
>>>>use them unless clearly indicated.
>>>>
>>>>Garry
>>>>
>>>>At Thu, 24 Apr 2008, Efrain Ramirez wrote:
>>>>>
>>>>>Agree!!!!
>>>>>
>>>>>Ef
>>>>>
>>>>>At Thu, 24 Apr 2008, R. Daniel Braun wrote:
>>>>>>
>>>>>>Steroids do more than prevent RDS. They also decrease incidence of IVH and
>>>>>>NEC, which can still occur after 34 weeks. Risk of giving steroids is ??????
>>>>>>
>>>>>>Dan
>>>>>>
>>>>>>On Thu, Apr 24, 2008 at 9:05 AM, Andrew Folley <agfolley@hotmail.com> wrote:
>>>>>>
>>>>>>> I must have missed how the diagnosis of IUGR was made?agf
>>>>>>>
>>>>>>> > Date: Thu, 24 Apr 2008 06:11:49 -0500
>>>>>>> > From: cdsb@bellsouth.net
>>>>>>> > To: ob-gyn-l@mail.obgyn.net
>>>>>>> > Subject: RE: What's next
>>>>>>> >
>>>>>>> > I don't give steroids after 34 weeks either. And Garry is right, the baby
>>>>>>> > isn't thriving, it's small.
>>>>>>> >
>>>>>>> > But if the fetus were say 30 weeks with IUGR, but with Reactive NST and
>>>>>>> 8/8
>>>>>>> > BPP, then I think there wouldn't be such a rush to delivery.
>>>>>>> >
>>>>>>> > So the real question here I think is given an IUGR fetus with perfect
>>>>>>> > testing, what is the EGA we would electively deliver?
>>>>>>> >
>>>>>>> > Everyone may have a different answer. Here is an example of there being
>>>>>>> 10
>>>>>>> > different ways to do something in medicine and nine of them not being
>>>>>>> wrong.
>>>>>>> >
>>>>>>> > Charles
>>>>>>> >
>>>>>>> > -----Original Message-----
>>>>>>> > From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Garry
>>>>>>> E.
>>>>>>> > Siegel, M.D.
>>>>>>> > Sent: Wednesday, April 23, 2008 10:47 PM
>>>>>>> > To: Multiple recipients of list OB-GYN-L
>>>>>>> > Subject: Re: What's next
>>>>>>> >
>>>>>>> > Over 34 weeks--no steroids unless amnio done and lung maturity not
>>>>>>> > proven.
>>>>>>> >
>>>>>>> > Yes, the late preterm baby alluded to in ACOG's Committe Bulletin has
>>>>>>> > more morbidity, etc., but this baby is far from thriving inside.
>>>>>>> >
>>>>>>> > Reassuring testing is nice, but nicer is a baby in the nursery.
>>>>>>> >
>>>>>>> > Deliver her, my friend.
>>>>>>> >
>>>>>>> > Garry
>>>>>>> >
>>>>>>> > At Wed, 23 Apr 2008, Efrain Ramirez wrote:
>>>>>>> > >
>>>>>>> > >No fetal weight gain at all in the last 2 weeks.. umbilical artery
>>>>>>> > >doppler normal.. MCA not done.. mother perceives fewer FM's.. just
>>>>>>> > >like the other pregnancy.
>>>>>>> > >Definitive asymmetric IUGR.
>>>>>>> > >Level III NICU .. I had to deliver in the last year to babies at 26
>>>>>>> > >weeks .. doing well..
>>>>>>> > >Steroids? - it's a Democratic Primary..
>>>>>>> > >Legally speaking an unexpected IUFD would be hard to defend... NICU
>>>>>>> > >complications, IMHO, easier.
>>>>>>> > >Thanks to all.. recommendations well taken.
>>>>>>> > >
>>>>>>> > >Ef
>>>>>>> > >
>>>>>>> > >At Wed, 23 Apr 2008, art fougner, md wrote:
>>>>>>> > >>
>>>>>>> > >>Middle cerebral artery doppler? Uterine artery doppler?
>>>>>>> > >>If all normal, would suggest (unencumbered by data) twice weekly nst's
>>>>>>> > >>with AFI's, weekly dopplers and elective delivery at term.
>>>>>>> > >>
>>>>>>> > >>Art
>>>>>>> > >>
>>>>>>> > >>Just my opinion. I could be wrong.
>>>>>>> > >>
>>>>>>> > >>At Wed, 23 Apr 2008, Efrain Ramirez wrote:
>>>>>>> > >>>
>>>>>>> > >>>30 some G2, P1 - previous C/S - IUGR - at 36 weeks - apparently no
>>>>>>> > >>>reassuring FHR's.2 weeks at NICU.. at present 34 w and 5 d.. BPP
>>>>>>> > >>>10/10, EFW - 1500-1600 below 5th.. normal umbilical Doppler .. what's
>>>>>>> > >>>next?
>>>>>>> > >>>
>>>>>>> > >>>Ef
>>>>>>> > >>>
>>>>>>> > >>>--
>>>>>>> > >>>"I can accept failure, but I can't accept not trying." - Michael
>>>>>>> Jordan
>>>>>>> > >>>
>>>>>>> > >>--
>>>>>>> > >>art fougner, md
>>>>>>> > >>"May The Wings of Liberty Never Lose a Feather." - Jack Burton
>>>>>>> > >>
>>>>>>> > >--
>>>>>>> > >"I can accept failure, but I can't accept not trying." - Michael Jordan
>>>>>>> > >
>>>>>>> >
>>>>>>> > --
>>>>>>> > Garry E. Siegel, M.D.
>>>>>>> > Private Practice
>>>>>>> > Roswell, GA
>>>>>>> >
>>>>>>>
>>>>>>> ------------------------------
>>>>>>> Make i'm yours. Create a custom banner to support your cause.<http://im.live.com/Messenger/IM/Contribute/Default.aspx?source=TXT_TAGHM_MSN_Make_IM_Yours>
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>>>>>>--
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>R. Daniel Braun, MD FACOG(L) ABMP CMTh
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>Professor Emeritus
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>> ------------------------------
>>>>>>> ------------------------------
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>>>>>>> ------------------------------
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>>>>>>Dept. of Obstetrics and Gynecology
>>>>>>> ------------------------------
>>>>>>Indiana U. School of Medicine
>>>>>>> ------------------------------
>>>>>>
>>>>>>R. Daniel Braun
>>>>>>
>>>>>>"Science without Religion is LAME; Religion without Science is BLIND"
>>>>>>Einstein 1941
>>>>>>
>>>>>--
>>>>>"I can accept failure, but I can't accept not trying." - Michael Jordan
>>>>>
>>>>--
>>>>Garry E. Siegel, M.D.
>>>>Private Practice
>>>>Roswell, GA
>>>>
>>>--
>>>"I can accept failure, but I can't accept not trying." - Michael Jordan
>>>
>>--
>>JD. Stewart, MD
>>MFM up too late all night, every night...still 10 years later
>>
>--
>art fougner, md
>"May The Wings of Liberty Never Lose a Feather." - Jack Burton
>
--
"I can accept failure, but I can't accept not trying." - Michael Jordan