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Re: GYN: New Blood Test for Ovarian Cancer?From: Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C. (johnprov@sympatico.ca)Thu Feb 14 16:51:21 2008
At Thu, 14 Feb 2008, art fougner, md wrote: > >The phase II clinical trial led by Mor included 500 patients -- 350 >healthy controls and 150 ovarian cancer patients. Mor and colleagues >validated the previous research -- which showed 95 percent effectiveness >-- and used a new platform called multiplex technology to simplify the >test into one single reaction using very small amounts of serum from the >blood. > >The new platform uses six protein biomarkers instead of four, increasing >the specificity of the test from 95 percent to 99.4 percent, Mor said. > >"This is the most sensitive and specific test currently available," Mor >said in a statement. "Previous tests recognized 15 percent to 20 >percent of new tumors > >http://www.upi.com/NewsTrack/Health/2008/02/13/blood_test_detects_ovarian_cancer_early/8345/ > >Fingers crossed ... > >Art > > I remember doing a CME review on this some 3 years ago in Ob\Gyn survey, it’s based on proteometics basically a complex statistical analysis of proteins expressed in serum, the same techniques are being applied as a test for prem-labor. I would definitely like to see some study or trial in a high risk sub group like BRAC1&2 the results could be very interesting. The one thing that I would ask would be are the cancers being found early enough to make a difference, by the time proteins are being expressed in the serum the stage or tumor bulk may be significant. The concept is very different than a genetic marker where you can quote a percentage risk of getting cancer; basically it presumes the cancer is making these proteins and already present.
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Take care, John
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