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Re: Magnesium Sulfate May Prevent CP From: R. Daniel Braun (rd.braun@gmail.com) Fri Feb 1 12:14:43 2008 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Richard D. Kaplan: "endometriosis?" Previous message: allanho@aol.com: "Re: BSO without hysterectomy" Here it is! Dan Am J Obstet Gynecol 2002 Jun;186(6):1111-8 Association between the use of antenatal magnesium sulfate in preterm labor and adverse health outcomes in infants. Mittendorf R, Dambrosia J, Pryde PG, Lee KS, Gianopoulos JG, Besinger RE, Tomich PG. Department of Obstetrics and Gynecology, Loyola University Medical Center, Maywood, IL 60153, USA. rmitten@lumc.edu <rmitten@lumc.edu?subject=Re: MgSO4 -- Magnesium Sulfate -- As A Tocolytic> OBJECTIVE: The purpose of this study was to determine whether the use of antenatal magnesium sulfate prevents adverse outcomes (neonatal intraventricular hemorrhage, periventricular leucomalacia, death, and cerebral palsy). STUDY DESIGN: In a controlled trial, we randomized mothers in preterm labor to magnesium sulfate, "other" tocolytic, or placebo. At delivery, umbilical cord blood was collected for the later determination of serum ionized magnesium levels. Neonatal cranial ultrasound scans were obtained periodically for the diagnosis of intraventricular hemorrhage and periventricular leucomalacia. Among survivors, the diagnosis of cerebral palsy was made at age 18 months. RESULTS: Children with adverse outcomes had higher umbilical cord magnesium levels at delivery. In regression models that controlled for confounders, which included very low birth weight, magnesium remained a significant risk factor (adjusted odds ratio, 3.7; 95% CI, 1.1-11.9; P =.03). CONCLUSION: Contrary to original hypotheses, this randomized trial found that the use of antenatal magnesium sulfate was associated with worse, not better, perinatal outcome in a dose-response fashion. On Feb 1, 2008 12:40 AM, Bernard Cristalli <bcrist@club-internet.fr> wrote: > Can you find the references of that? > B > > R. Daniel Braun a écrit : > > And 2-3 yrs ago, they had to stop a study in Chicago early because it > > caused cerebral palsy. > > > > Dan > > > > On Jan 31, 2008 4:30 PM, Meenan, Anna <annam@uic.edu > > <mailto:annam@uic.edu>> wrote: > > > > Are they giving it IV or PO? Is it just one dose before delivery > > or what? > > > > Anna Meenan, MD > > > > >only thing about epsom salts..is that is gives one horrible > > >diarrhoea...indeed it used to be taken to try and bring on labor in > > >post-dates.... > > >so maybe giving it to pre-term mothers might not be ideal if one is > > >trying to have them hold off delivering. > > >though giving mgso4 IV doesn't give the same "bowel" problem as far > > >as I know...but I do not think epsom salts would be ideal...besides > > >it tastes horrid. > > >frances wren >> > >----- Original Message ----- From: "art fougner, md" > > <evsono@pipeline.com <mailto:evsono@pipeline.com>> > > >To: "Multiple recipients of list OB-GYN-L" > > <ob-gyn-l@mail.obgyn.net <mailto:ob-gyn-l@mail.obgyn.net>> > > >Sent: Thursday, January 31, 2008 8:52 AM > > >Subject: OB: Magnesium Sulfate May Prevent CP > > > > > >>Study: Giving moms magnesium sulfate cuts risk of cerebral palsy > in > > >>extreme premature babies > > >> > > >>Doctors can cut the risk of cerebral palsy in half for very > > premature > > >>babies by giving their mothers magnesium sulfate just before > > they give > > >>birth, new research shows. > > >> > > >>The mineral compound, also known as Epsom salts, is already used > to > > >>treat preganancy-related high blood pressure and to stop early > > labor. > > >>Doctors should consider giving it to women about to deliver an > > extremely > > >>preterm infant, said one of the researchers, Dr. John Thorp of > the > > >>University of North Carolina. > > >> > > >>The research was led by Dr. Dwight Rouse at the University of > > Alabama > > >>at Birmingham and was presented Thursday at a meeting of the > > Society for > > >>Maternal-Fetal Medicine in Dallas. > > >> > http://www.iht.com/articles/ap/2008/01/31/america/NA-MED-US-Pregnancy-Cerebral-Palsy.php > > >> > > >>Medicine Swings Like A Pendulum Do ... > > >> > > >>Art > > >> > > >>-- > > >>art fougner, md > > >>"May The Wings of Liberty Never Lose a Feather." - Jack Burton > > >> > > >>-- > > >>No virus found in this incoming message. > > >>Checked by AVG Free Edition. > > >>Version: 7.5.516 / Virus Database: 269.19.16/1251 - Release Date: > > >>1/30/2008 9:29 AM > > > > -- > > R. Daniel Braun, MD FACOG(L) CMT > > Professor Emeritus > > Dept. of Obstetrics and Gynecology > > Indiana U. School of Medicine > > > > R. Daniel Braun > > > > "Science without Religion is LAME; Religion without Science is > > BLIND" > > Einstein 1941 > -- -- R. Daniel Braun, MD FACOG(L) CMT Professor Emeritus Dept. of Obstetrics and Gynecology Indiana U. School of Medicine R. Daniel Braun "Science without Religion is LAME; Religion without Science is BLIND" Einstein 1941 Next message: Richard D. Kaplan: "endometriosis?" Previous message: allanho@aol.com: "Re: BSO without hysterectomy"

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