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Re: BSO without hysterectomyFrom: Dr. John Provatopoulos B.Sc. M.D.C.M. F.R.S.C. (johnprov@sympatico.ca)Fri Feb 1 09:50:12 2008
At Thu, 31 Jan 2008, AllanHo@aol.com wrote: > >In a message dated 1/30/2008 10:04:23 PM Eastern Standard Time, >johnprov@sympatico.ca writes: > >Actually the one's who are BRCA positive should be getting Hysts also, >the big path reviews from the Toronto Study showed early Falopian tube >CA which we all know act like ovarian CA , the Falopian CA was often in >the cornal part of the tube! > >-- >Take care, John >I guess the jury is still out on this one. The last article I read showed >no "exclusive proximal lesions" for BRCA positive women with Fallopian tube >CA. From what I have read, the S part of the BSO should suffice in reducing >the risk of Fallopian tube cancer. I would appreciate any references if that's >not the case. Thanks. > >Allan > Gynecol Oncol. 2001 Feb;80(2):176-80. Links Comment in: Gynecol Oncol. 2001 Nov;83(2):445. Gynecol Oncol. 2001 Nov;83(2):445-7. Occult cancer of the fallopian tube in BRCA-1 germline mutation carriers at prophylactic oophorectomy: a case for recommending hysterectomy at surgical prophylaxis.Paley PJ, Swisher EM, Garcia RL, Agoff SN, Greer BE, Peters KL, Goff BA. Department of OB/GYN, Division of Gynecologic Oncology, University of Washington School of Medicine, Seattle, Washington 98195, USA. OBJECTIVE: BRCA-1 and BRCA-2 germline mutations increase the risk of ovarian and breast cancer. Primary cancer of the fallopian tube is rare; however, recent evidence suggests that patients harboring a germline mutation conferring an increased risk of ovarian cancer may be at risk for fallopian tube cancer as well. We discuss the finding of occult fallopian tube cancer diagnosed at surgical prophylaxis in women harboring BRCA-1 mutations. METHODS/RESULTS: Two patients undergoing surgical prophylaxis to address an increase in ovarian cancer risk were discovered to harbor occult primary fallopian tube carcinoma on final pathology review. Mutational analysis confirmed the presence of a deleterious mutation in BRCA-1 in both patients. CONCLUSION: Currently, consensus opinions regarding ovarian cancer surgical prophylaxis in gene mutation carriers do not include hysterectomy as part of the preventative procedure. This report as well as a growing number of cases of fallopian tube cancer reported in known BRCA-1 and BRCA-2 mutation carriers has important implications for recommendations regarding surgical prophylaxis in these women. PMID: 11161856 [PubMed - indexed for MEDLINE
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Take care, John
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