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Richard Chudacoff, MD, FACOG
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From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Larry
Glazerman
Sent: Tuesday, October 30, 2007 3:57 AM
To: Multiple recipients of list OB-GYN-L
Subject: Re: HPV vaccine and resistance
Rick:
I'm an investigator for Gardasil (their current study in the 26-45 year old
female population). At our most recent investigator's meeting, this issue
came up. They gave several very elegant immunological reasons why this is
very unlikely to happen, which make sense to me. I can't begin to explain
the immunology, but one of the issues was that, unlike most bacteria, HPV
subtypes are synergistic, rather than competitive. Apparently there's good
data (don't ask how they got it) that this virus, again, unlike most
bacteria, hasn't had significant mutation in thousands of years.
Larry
Larry R. Glazerman, MD, FACOG
St. Luke's Center for Advanced Gynecologic Care
250 Cetronia Road
Suite 305
Allentown PA 18104
484-223-3279
484-223-2830 FAX
glazerl@slhn.org
On Oct 29, 2007, at 6:54 PM, Richard Chudacoff wrote:
I think most of you are aware of the recent discovery of a virulent and
resistant strain of Strep pneumonia in upstate New York. It appears this is
a result of a vaccination program started about 8 years ago to prevent ear
infections in neonates and kids. Now, there is this resistant strain, and
only antibiotics withheld from pediatric patients is the past seem to work.
I still believe that the MRSA endemic is related to the ubiquitous use of
antibacterial soaps. My question is this: why won't the same thing happen
with HPV? Right now HPV is a little more than a nuisance in the regularly
screened population. What happens when it becomes more aggressive due to the
selecting out of relatively easy to treat strains? I am feeling reluctant to
giving this vaccine although now it is out there perhaps the resistance is
inevitable.
Just my opinion, but I could be wrong...then again, I could be right
Richard Chudacoff, MD, FACOG
Las Vegas International Center for Advanced Gynecologic Care
(Specializing in minimally and non-invasive surgery)
2481 Professional Court
Las Vegas, NV 89128
TEL: 702-485-8893
FAX: 702-974-0945
www.lasvegasgyncenter.com <http://www.lasvegasgyncenter.com/>
www.exablateoflasvegas.com <http://www.exablateoflasvegas.com/>
