Re: Methotrexate
From: Raymond Stephen (stephen.raymond@dhhs.tas.gov.au)
Mon Apr 30 22:13:52 2007
I wish I could publish my data, but it is all in South Africa and
probably lost in the Medical Records department.
Steve
________________________________
From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of R.
--
________________________________
Daniel Braun
Sent: Tuesday, 1 May 2007 2:55 AM
To: Multiple recipients of list OB-GYN-L
Subject: Re: Methotrexate
So it looks like therre is a higher number o fpatients requiring 2 or 3
courses of treatment. The total number of pregnancies is way too small
to conclude that.
Steve,
Publish your data!
Dan
On 4/29/07, art fougner, md <evsono@pipeline.com> wrote:
Am J Obstet Gynecol. 2002 Jun;186(6):1192-5.
Oral methotrexate for treatment of ectopic pregnancy.
Lipscomb GH, Meyer NL, Flynn DE, Peterson M, Ling FW.
Department of Obstetrics and Gynecology, University of Tennessee Health
Science Center, Memphis, USA.
OBJECTIVE: The purpose of this study was to evaluate oral methotrexate
tablets in the treatment of ectopic pregnancy. STUDY DESIGN: Patients
with a diagnosis of ectopic pregnancy were offered oral methotrexate
tablets rather that intramuscular injection. Oral methotrexate was
given in 2 divided doses 2 hours apart at a dose of 60 mg/m(2) with
standard 2.5 mg methotrexate tablets. Patients were followed up with
the use of the same protocol that was used typically for intramuscular
methotrexate. RESULTS: Nineteen of 22 patients (86%) were successfully
treated. There was no statistical difference between patients who were
treated successfully or unsuccessfully, with respect to initial human
chorionic gonadotropin titers (P =.55), ectopic size (P =.77), or
methotrexate dose (P =.18). Nineteen of 22 patients (86%) had increased
pain during treatment. Outside of pain, gastrointestinal side effects
were the most common. Thirty-two percent of patients required more than
one treatment cycle. CONCLUSION: Oral methotrexate can be used to treat
ectopic pregnancy successfully, but there are few advantages to
recommend its use over intramuscular methotrexate.
Art
At Sun, 29 Apr 2007, R. Daniel Braun wrote:
>
>Steve,
>Give us a reference ofr that. OR put all your data together and publish
it.
>Dan
>
>On 4/29/07, Raymond Stephen <stephen.raymond@dhhs.tas.gov.au> wrote:
>>
>> Yes I have used oral exclusively in the last decade. The dose is
the
>> same, but be aware that it is available in small dose tablets (I
think 2 or
>> 2.5mg), so ensure that he stocks the larger dose tablets otherwise
your
>> patients have to swallow 20 tablets at a time!
>>
>> Steve Raymond
>>
>> ------------------------------
>>
>> ------------------------------
>> ------------------------------
>> ------------------------------
>> *From:* ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] *On Behalf Of
*Elrod,
>> ------------------------------
>> Darryl G Maj 48 MDOS/SGOBO
>> ------------------------------
>> *Sent:* Friday, 27 April 2007 6:47 PM=20
>> ------------------------------
>> *To:* Multiple recipients of list OB-GYN-L
>> *Subject:* Methotrexate
>>
>> Does anyone have any experience with ORAL methotrexate for treatment
of
>> ectopic pregnancy? Our pharmacist is looking to try and get away
from
>> having to stock IM methotrexate.
>>
>> Thanks,
>>
>> Glen
>>
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>--
>R. Daniel Braun, MD FACOG(L) CMT
>Professor Emeritus
>Dept. of Obstetrics and Gynecology
>Indiana U. School of Medicine
>
>R. Daniel Braun
>
> "The way to health is an aromatic bath and scented massage
everyday".
> Hippocrates
>
--
art fougner, md
"May The Wings of Liberty Never Lose a Feather." - Jack Burton
--
R. Daniel Braun, MD FACOG(L) CMT
Professor Emeritus
Dept. of Obstetrics and Gynecology
Indiana U. School of Medicine
R. Daniel Braun
"The way to health is an aromatic bath and scented massage
everyday".
Hippocrates
CONFIDENTIALITY NOTICE AND DISCLAIMER
The information in this transmission may be confidential and/or protected by legal professional privilege, and is intended only for the person or persons to whom it is addressed. If you are not such a person, you are warned that any disclosure, copying or dissemination of the information is unauthorised. If you have received the transmission in error, please immediately contact this office by telephone, fax or email, to inform us of the error and to enable arrangements to be made for the destruction of the transmission, or its return at our cost. No liability is accepted for any unauthorised use of the information contained in this transmission. If the transmission contains advice, the advice is based on instructions in relation to, and is provided to the addressee in connection with, the matter mentioned above. Responsibility is not accepted for reliance upon it by any other person or for any other purpose.
