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Re: Progesterone for prevention of preterm birth From: Raymond Stephen (stephen.raymond@dhhs.tas.gov.au) Mon Jan 29 19:42:46 2007 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Efrain Ramirez: "Re: Question about pap test frequency" Previous message: Raymond Stephen: "Re: Terbutaline/acute fetal 'distress'" In reply to: Bernard Cristalli: "Re: Progesterone for prevention of preterm birth" Next in thread: art fougner, md: "Re: Progesterone for prevention of preterm birth" Obstetrics & Gynecology 1979;54:412-418 © 1979 by The American College of Obstetricians and Gynecologists High-risk prematurity--progestin treatment and steroid studies JW Johnson, PA Lee, AS Zachary, S Calhoun, and CJ Migeon Studies have been undertaken regarding the efficacy and modus operandi of 17 alpha-hydroxyprogesterone caproate (17 alpha-OHP-C) in preventing premature labor in high-risk patients. In a total of 70 patients, the treated patient population had a prematurity rate (12.8%) and a perinatal mortality rate (5%) which were significantly lower than those of the total placebo or untreated patient group (40.9 and 25%, respectively). In addition, sequential plasma steroid values were determined in 21 patients, 10 of whom delivered prematurely. The results indicate that low plasma progesterone (P) and 17 alpha-hydroxyprogesterone (17 alpha-OHP) levels precede the onset of preterm labor by weeks. Successful treatment with 17 alpha-OHP-C was characterized by elevated P levels. Plasma estradiol (E2) and cortisol (C) values did not vary with time of delivery or treatment. These findings support the progesterone block theory as an important mechanism affecting preterm delivery in this high-risk population. Steve Raymond ________________________________ From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of = -- ________________________________ Bernard Cristalli Sent: Tuesday, 30 January 2007 4:43 AM To: Multiple recipients of list OB-GYN-L Subject: Re: Progesterone for prevention of preterm birth Sorry, rather DES than Thalidomide :-) This literature has been written way before this and we used progesterone ages ago. You'll find below some relatively recent articles before we find it ineffective. Don't try to invent tepid water. Bernard Audra P, Mellier G, Faguer B, Dargent D, Noblot G, Fournier S. Related Articles, Links Abstract [The administration of micronized progesterone in the treatment of threatened premature labor] Rev Fr Gynecol Obstet. 1991 Dec;86(12):751-6. French. PMID: 1775892 [PubMed - indexed for MEDLINE] 5: Noblot G, Audra P, Dargent D, Faguer B, Mellier G. Related Articles, Links Abstract The use of micronized progesterone in the treatment of menace of preterm delivery. Eur J Obstet Gynecol Reprod Biol. 1991 Jul 25;40(3):203-9. PMID: 1879595 [PubMed - indexed for MEDLINE] 6: Sitruk-Ware R, Bricaire C, De Lignieres B, Yaneva H, Mauvais-Jarvis P. Related Articles, Links Abstract Oral micronized progesterone. Bioavailability pharmacokinetics, pharmacological and therapeutic implications--a review. Contraception. 1987 Oct;36(4):373-402. Review. PMID: 3327648 [PubMed - indexed for MEDLINE] 7: Ferre F, Uzan M, Jolivet A, Janssens Y, Tanguy G, Sureau C, Cedard L. Related Articles, Links Abstract Influence of the oral administration of micronized progesterone on plasma and tissue levels of steroids in human pregnancy. Acta Physiol Hung. 1985;65(4):443-51. Le 29 janv. 07 à 17:40, AFuentes a écrit : I am sorry you haven't taken the time to familiarize yourself with the literature...and please don't compare 17P with Thalidomide...I can do without the sarcasm. BTW, next week in San Francisco, there will be other data presented on 17p at the SMFM meeeting..I will be more than happy to share them with you, so you can get educated. A.Fuentes Director Maternal Fetal Center -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Bernard Cristalli Sent: Monday, January 29, 2007 8:27 AM To: Multiple recipients of list OB-GYN-L Subject: Re: Progesterone for prevention of preterm birth . and ineffective in both indications. Le 29 janv. 07 à 14:15, Meisel Richard L. a écrit : Its worth noting that the 17 OH progesterone is for the prevention of of preterm delivery and not for the treatment of preterm labor. R L Meisel, MD Next message: Efrain Ramirez: "Re: Question about pap test frequency" Previous message: Raymond Stephen: "Re: Terbutaline/acute fetal 'distress'" In reply to: Bernard Cristalli: "Re: Progesterone for prevention of preterm birth" Next in thread: art fougner, md: "Re: Progesterone for prevention of preterm birth"

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