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Re: early onset severe IUGR and ambiguous genitalia without any other anomaly From: JD Stewart,MD (jdstewartmfmob@sbcglobal.net) Thu Nov 2 12:11:25 2006 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Rafael Haciski: "Re: IMPLANON" Previous message: Lalehan Kutlay: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" In reply to: Lalehan Kutlay: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" Next in thread: art fougner, md: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" Reply: art fougner, md: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" At Thu, 2 Nov 2006, Lalehan Kutlay wrote: > >Maternal trombocyte count was normal and there is no evidence of >thrombophilia WAS THE TESTING ACTUALLY RUN? FAMILY HISTORY/PREGNANCY COURSE MAY MISS CARRIERS> Baby was quite well in first 36 hours. >Autopsy report and the results of second chromosome analysis is not >available yet . > >I've read about paternal monosomies(esp. 7)and minor chromosomal >anomalies at 7,13 18 may result in somehow 'hard to explain' IUGR >cases.Is this can be the cause. MONOSOMY WOULD HAVE BEEN PICKED UP AS A 45,XY. DO YOU MEAN UNIPARENTAL DISOMY? (BOTH CHROMOSOMES OF PATERNAL OR MATERNAL ORIGIN?) YOU MENTIONED THE PLACENTA LOOKED NORMAL..ISLANDS OF MOSAICISM WITHIN THE PLACENTA MAY LOOK NORMAL ON U/S AND GROSS EXAM BUT BE QUITE DYSFUNCTIONAL AND TAKE UP AN UNEXPECTED DISPROPORTIONATE SHARE OF THE PLACENTAL PERFUSION IN A VASCULAR STEAL SITUATION. RECOMMEND SAMPLING DIFFERENT SITES AND ADDITIONAL CELL LINE CULTURES IF THIS IS SUSPECTED> >> -- JD. Stewart, MD MFM up too late all night, every night Two places you never want to be the "Great Case of the Week"- the OB ward and the courtroom. Next message: Rafael Haciski: "Re: IMPLANON" Previous message: Lalehan Kutlay: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" In reply to: Lalehan Kutlay: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" Next in thread: art fougner, md: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly" Reply: art fougner, md: "Re: early onset severe IUGR and ambiguous genitalia without any other anomaly"

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