Echinococcal cyst in pregnancy

From: Elrod, Darryl G MAJ 48 MDOS/SGOBO (Darryl.elrod@LAKENHEATH.AF.MIL)
Tue Feb 28 10:29:46 2006


Group,

We have just had a 26 yo G2P1 at 19 wks present with diffuse abdominal pain, vomiting, WBC count of 17K. Her workup included abdominal ultrasound that showed a 12 cm liver cyst, c/w echinococcal cyst. CT scan the next morning (today) showed probable rupture of this cyst with an increased amount of free fluid.

Because her temperature increased to 101, her WBC count increased to 19K and the findings of the CT scan, the general surgeons decided to operate and drain the cyst.

At surgery, there was free fluid noted. The cyst was indeed ruptured through a small hole. 150ml of clear fluid was removed from the cyst. The cyst was opened and a large amount of white opaque gelatinous tissue was removed. There were also noted some typical echinococcal cysts.

My question for the group is more a question of management for the remainder of the pregnancy. Treatment options appear to be mebendazole or albendazole for 3-6 months. Both of these are listed as Category C drugs and Reprotox shows possibly some benefit of mebendazole over albendazole, but mostly for first trimester exposure.

Has anyone continued drug therapy for this long or have experience at all with treating this?

Thanks,

Glen

//SIGNED//

D. Glen Elrod, Maj., USAF, MC

Obstetrician/Gynecologist

Chief of Obstetrics

48 MDOS/SGOBO

RAF Lakenheath, England

Telephone DSN: 314-226-8130

Comm: +44 (0) 1638 52 8130

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