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Re: Ortho Evra From: l.glazerman@rcn.com Tue Feb 28 08:44:22 2006 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: ainsron: "Re: Prolapsed cord" Previous message: DoctorJoe@aol.com: "Re: Gyn:  Our friends, the ureters" Sorry. Twice the relative risk of venous thromboembolism. >---- Original message ---- >Date: Tue, 28 Feb 2006 09:15:10 -0600 >From: babycatchers@aol.com >Subject: Re: Ortho Evra >To: Multiple recipients of list OB-GYN-L <ob-gyn- l@dns.obgyn.net> > > Excuse my ignorance- could you state what 2X RR VTE > stands for, please? > > -----Original Message----- > From: Larry Glazerman <l.glazerman@rcn.com> > To: Multiple recipients of list OB-GYN-L > <ob-gyn-l@dns.obgyn.net> > Sent: Mon, 27 Feb 2006 21:38:14 -0600 > Subject: RE: Ortho Evra > > I'm on Ortho's speaker's bureau. The bottom line is that despite the new > info about a 60% higher average blood level with Evra than with OCs, there > is NO data confirming an increased risk of any side effect. > > In conjunction with the FDA, Ortho has sponsored several epidemiologic > studies. One is now in press, and, to summarize, shows no difference in VTE > between Evra and a 35 mcg pill. A second study, equally well done, not yet > published, apparently shows an increase from 1-2/10,000 VTE with OC to 2-4 > /10,000 with Evra. This is a RR of ~2, but an absolute risk of 1-2/10,000 > patients (very low, IMHO). Also, it should be noted that other current > contraceptives have significant warnings in their package inserts: > > Seasonale - significantly higher bleeding rates > Yasmin - ?problems with K+ due to spironolactone like effect > NuvaRing - 2X RR VTE > > The fact remains that all of these hormonal contraceptives are very safe, > probably none any safer or more dangerous significantly than any other, and > ALL much safer than pregnancy!!!!!! > > Waiting for the flames :) > > Larry R. Glazerman, MD > > 610-402-0161 > l.glazerman@rcn.com > > -----Original Message----- > From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Garry E. > Siegel, M.D. > Sent: Monday, February 27, 2006 9:54 PM > To: Multiple recipients of list OB-GYN-L > Subject: Gyn: Ortho Evra > > The nice Ortho rep brought in a lunch today to talk about the bad rap > Evra has gotten, yet it is (according to him) the most prescribed > hormonal contraceptive in the US. > > Has anyone changed their habits regarding this since the poop has hit > the fan, i.e. the FDA made Ortho change the labeling and some brouhaha > about strokes? Has anyone seen the science on it? > > Garry > > -- > Garry E. Siegel, M.D. > Private Practice > Roswell, GA Next message: ainsron: "Re: Prolapsed cord" Previous message: DoctorJoe@aol.com: "Re: Gyn:  Our friends, the ureters"

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