Re: Ortho Evra
From: Marie Harkins (mharkins@twcny.rr.com)
Tue Feb 28 06:57:01 2006
Larry,
Are you saying that the NuvaRing also has 2X RR VTE? I haven't seen
this data yet. Has it been published? I wondered if it would have a
similar profile of estrogen exposure as OrthoEvra .
Many women I have counseled about the new data on Ortho Evra have opted
to continue with it anyway. Most are women who forget to take a daily
OC and do not want the risk of pregnancy.
--
Marie Harkins, CNM
Ithaca, NY
On Monday, February 27, 2006, at 10:38 PM, Larry Glazerman wrote:
> I'm on Ortho's speaker's bureau. The bottom line is that despite the
> new
> info about a 60% higher average blood level with Evra than with OCs,
> there
> is NO data confirming an increased risk of any side effect.
>
> In conjunction with the FDA, Ortho has sponsored several epidemiologic
> studies. One is now in press, and, to summarize, shows no difference
> in VTE
> between Evra and a 35 mcg pill. A second study, equally well done, not
> yet
> published, apparently shows an increase from 1-2/10,000 VTE with OC to
> 2-4
> /10,000 with Evra. This is a RR of ~2, but an absolute risk of
> 1-2/10,000
> patients (very low, IMHO). Also, it should be noted that other current
> contraceptives have significant warnings in their package inserts:
>
> Seasonale - significantly higher bleeding rates
> Yasmin - ?problems with K+ due to spironolactone like effect
> NuvaRing - 2X RR VTE
>
> The fact remains that all of these hormonal contraceptives are very
> safe,
> probably none any safer or more dangerous significantly than any
> other, and
> ALL much safer than pregnancy!!!!!!
>
> Waiting for the flames :)
>
> Larry R. Glazerman, MD
>
> 610-402-0161
> l.glazerman@rcn.com
>
> -----Original Message-----
> From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of
> Garry E.
> Siegel, M.D.
> Sent: Monday, February 27, 2006 9:54 PM
> To: Multiple recipients of list OB-GYN-L
> Subject: Gyn: Ortho Evra
>
> The nice Ortho rep brought in a lunch today to talk about the bad rap
> Evra has gotten, yet it is (according to him) the most prescribed
> hormonal contraceptive in the US.
>
> Has anyone changed their habits regarding this since the poop has hit
> the fan, i.e. the FDA made Ortho change the labeling and some brouhaha
> about strokes? Has anyone seen the science on it?
>
> Garry
>
> --
> Garry E. Siegel, M.D.
> Private Practice
> Roswell, GA
>
