Re: OB: Mid trimester loss- a different perspective

From: JD Stewart,MD (jdstewartmfmob@sbcglobal.net)
Mon Nov 7 11:30:16 2005


Next pregnancy she will be 35yrs plus, worried about aneuploidy, fertility rates falling, and she will already assuming the worst and calling about aspirin,Folic acid, CVS -early amnio and a wreck.

I would try specimen chromosomes, counseling we may not get cells to grow with a 2wk old IUFD; screen for ANA/ f/u if positive; check for thrombophilias - genetic tests for MTHFR, Factor V Leyden, =/- Factor II and unlikely ATIII without a clot history in the family. Protein S/C/homocystein will be unreliable in this setting.

This approach will identify problems we can do something about in early pregnancy, and I think a discussion of the costs versus the possible benefits should be presented to the patient, and let her ultimately decide.

I have a problem with deciding not to offer this without fully discussing it with the patient.

My $.02.

JDS

At Sun, 6 Nov 2005, Garry E. Siegel, M.D. wrote: >
>34 YO P1001 at 14.5 weeks presents for routine visit, no problems, and
>has no FHTs. Scan shows a 12.5 week (CRL) missed Ab, and her dates and
>viability had been established by a 9 week scan.
>
>Her history is negative and she is to undergo a D and C.
>
>Would you send chromosomes?
>Depending of that answer, and depending on the result, would you
>evaluate more fully, i.e. anti-phopholipid testing, thromophilia
>testing, etc.?
>
>Garry
>
>--
>Garry E. Siegel, M.D.
>Private Practice
>Roswell, GA
>

--
JD. Stewart, MD
MFM up too late all night, every night




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