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Re: HR HPV in 51 yoFrom: Atkinson, Samuel M (ATKINSONS@mail.ecu.edu)Tue Aug 23 09:57:59 2005
I believe that with HR HPV following with Paps q six mos and unless PAP goes to HGSIL nothing else need be done. Remember, there is a long span of time from infection to actual CIS or worse..usually greater than 10 years. Cryo only creates more metaplastic cells and HPV loves (and only reproduces in)metaplastic cells. Have seen HPV proliferate massively after cryo and cone..Do not see justification for vag hyst..but that is only treatment with any potential of protecting pt. Cryo is for extant disease i.e. Severe dysplasia or higher. It will not get rid of virus. Hopefully Merck will survive long enough to bring their HPV vaccine to market. Studies suggest it will make ameliorate HPV infection so next 12-18 mos it should be out..I know they are producing it already..as is Glaxo , I believe. S -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net] On Behalf Of Joanne Bulley, MD Sent: Monday, August 22, 2005 5:05 PM To: Multiple recipients of list OB-GYN-L Subject: HR HPV in 51 yo What would you do .... 51yo G2P2 past history of normal paps new marriage fall 2003 Pap 7/04 ASCUS +HR-HPV Colpo 8/04 biopsies without dysplasia, cervical polyp removed (no dysplasia) Pap with Colpo 2/05: Pap normal; Biopsy CIN 1 with HPV and anothe endocervical polyp without dysplasia Pap with Colpo 8/05: Pap normal; Biopsies x2 both with CIN 1 and HPV. Colposcopically looks like squamous metaplasia throughout the transition zone with the tiny openings for the mucus of the endocervical "glands" with some very mild acetowhite. Would you 1. Pap with colpo and biospy every 6 moonths (or some other interval) 2. Cryo or laser or LEEP now? (which would you do) 3. Something else?
-- Joanne Bulley, MD Keene, NH, USA
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