Re: OB: Good, Bad, Or Ugly?
From: Gerald P. Rodríguez (geraldpr@cybermesa.com)
Wed Aug 17 10:18:11 2005
You mean the "All the News that Misfits, We Print" newspaper.
Gerald P. Rodrķguez, M.D., FACOG
Santa Fe
~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
>----- Original Message -----
From: "art fougner, md" <evsono@pipeline.com>
To: "Multiple recipients of list OB-GYN-L" <ob-gyn-l@dns.obgyn.net>
Sent: Wednesday, August 17, 2005 9:06 AM
Subject: Re: OB: Good, Bad, Or Ugly?
>I used to respect the New York Times ...
>
> art
>
> At Wed, 17 Aug 2005, Charlie Chambers wrote:
>>
>>I did see that. Of course, I like that it was published ONLINE. Not
>>exactly my most respected journal.
>>************************************************************************
>>****
>>************************************************************************
>>
>>--
>>Charlie Chambers
>>Hood River, OR
>>cchamber@alumni.rice.edu
>>
>>"Almost anything you do will seem insignificant but it is very important
>>that you do it....You must be the change you wish to see in the world"
>> -- Mahatma Ghandi.
>>************************************************************************
>>*******
>>************************************************************************
>>
>>On Aug 17, 2005, at 7:16 AM, art fougner, md wrote:
>>
>>> The company website has a reference section, among which is this:
>>>
>>> Fetal DNA detection in maternal plasma throughout gestation
>>> Received: 1 March 2005 Accepted: 16 April 2005 Published online: 20 May
>>> 2005
>>>
>>> Abstract The presence of fetal DNA in maternal plasma may represent a
>>> source of genetic material which can be obtained noninvasively. We
>>> wanted to assess whether fetal DNA is detectable in all pregnant women,
>>> to define the range and distribution of fetal DNA concentration at
>>> different gestational ages, to identify the optimal period to obtain a
>>> maternal blood sample yielding an adequate amount of fetal DNA for
>>> prenatal diagnosis, and to evaluate accuracy and predictive values of
>>> this approach. This information is crucial to develop safe and
>>> reliable
>>> non-invasive genetic testing in early pregnancy and monitoring of
>>> pregnancy complications in late gestation. Fetal DNA quantification in
>>> maternal plasma was carried out by real-time PCR on the SRY gene in
>>> male-bearing pregnancies to distinguish between maternal and fetal DNA.
>>> A cohort of 1,837 pregnant women was investigated. Fetal DNA could be
>>> detected from the sixth week and could be retrieved at any gestational
>>> week. No false-positive results were obtained in 163 women with
>>> previous embryo loss or previous male babies. Fetal DNA analysis
>>> performed blindly on a subset of 464 women displayed 99.4, 97.8 and
>>> 100%
>>> accuracy in fetal gender determination during the first, second, and
>>> third trimester of pregnancy, respectively. No SRY amplification was
>>> obtained in seven out of the 246 (2.8%) male-bearing pregnancies.
>>> Fetal
>>> DNA from maternal plasma seems to be an adequate and reliable source of
>>> genetic material for a noninvasive prenatal diagnostic approach.
>>>
>>> Silvia Galbiati1, Maddalena Smid2, Dania Gambini2, Augusto Ferrari2,
>>> Gabriella Restagno3, Elsa Viora4, Mario Campogrande4, Simona
>>> Bastonero4,
>>> Marco Pagliano5, Stefano Calza6, Maurizio Ferrari1, 7 and Laura
>>> Cremonesi1
>>>
>>> (1) Unit of Genomics for Diagnosis of Human Pathologies, IRCCS H. San
>>> Raffaele, Via Olgettina 58, 20132 Milan, Italy
>>> (2) Department of Obstetrics and Gynecology, IRCCS H. San Raffaele,
>>> Milan, Italy
>>> (3) Struttura Complessa Genetica Molecolare, A.O.O.I.R.M.-S. Anna,
>>> Torino, Italy
>>> (4) Centro di Ecografia e Diagnosi Prenatale, Ospedale S. Anna,
>>> Torino,
>>> Italy
>>> (5) Cattedra A, Universitą di Torino, Torino, Italy
>>> (6) Sezione di Statistica Medica e Biometria, Dipartimento di Scienze
>>> Biomediche e Biotecnologie, Universitą di Brescia, Brescia, Italy
>>> (7) Diagnostica e Ricerca S. Raffaele S.p.A., H. San Raffaele, Milan,
>>> Italy
>>>
>>> Source http://www.springerlink.com
>>>
>>> art
>>>
>>> At Wed, 17 Aug 2005, Charlie Chambers wrote:
>>>>
>>>> I think it shows what a rush we are in as a society. Willingness to
>>>> spend this kind of money when you will know for certain at delivery.
>>>> Also, to date, I can't recall off hand any studies that were 100%
>>>> accurate in terms of prediction when using probes for Y chromosome
>>>> sequences in maternal blood.
>>>>
>>>> **********************************************************************
>>>> **
>>>> **********************************************************************
>>>> ****
>>>>
>>>> --
>>>> **********************************************************************
>>>> **
>>>> **********************************************************************
>>>> Charlie Chambers
>>>> Hood River, OR USA
>>>> cchamber@alumni.rice.edu
>>>>
>>>> "...not because I regard fishing as being so terribly
>>>> important but because I suspect that so many of the other
>>>> concerns of men are equally unimportant-and not nearly
>>>> so much fun."
>>>> John Voelker
>>>> **********************************************************************
>>>> **
>>>> **********************************************************************
>>>> *****
>>>> **********************************************************************
>>>> **
>>>> **********************************************************************
>>>> On Aug 17, 2005, at 5:17 AM, art fougner, md wrote:
>>>>
>>>>> Kit makes it womb with a view
>>>>>
>>>>> BY MAGGIE HABERMAN
>>>>> DAILY NEWS STAFF WRITER
>>>>>
>>>>> Forget about sonograms and amniocentesis tests - a new take-home kit
>>>>> allows expectant moms to find out their baby's gender as early as
>>>>> five
>>>>> weeks into their pregnancy.
>>>>>
>>>>> "People just want to plan ahead, and this allows them to plan ahead
>>>>> even
>>>>> further," said Sherry Bonelli, president of pregnancystore.com, the
>>>>> online outlet selling the Baby Gender Mentor.
>>>>>
>>>>> Parents who buy the $25 kit get a tool to prick their fingers for a
>>>>> small blood sample that is sent to a lab in Massachusetts.
>>>>>
>>>>> For $250 in lab fees, the results come within 48 hours.
>>>>>
>>>>> The lab techs identify the baby's DNA in the mother's blood. If
>>>>> there's
>>>>> a Y chromosome found, parents can start buying blue onesies; if there
>>>>> isn't, it's pink wallpaper for the nursery.
>>>>>
>>>>> Bonelli said she has sold thousands of kits since they became
>>>>> available
>>>>> in June. Some couples want to prepare siblings for the arrival of a
>>>>> baby; one engaged couple wanted to coordinate their wedding favors
>>>>> with
>>>>> their unborn child's sex, she added.
>>>>>
>>>>> But some bioethicists fear that since the test is taken while the
>>>>> embryo
>>>>> is so unformed, some people will use it to end early pregnancies if
>>>>> they
>>>>> don't get the boy or girl they were hoping for.
>>>>>
>>>>> http://www.nydailynews.com/08-16-2005/city_life/story/337700p
>>>>> -288375c.html
>>>>>
>>>>> art
>>>>>
>>>>> --
>>>>> art fougner, md
>>>>>
>>>>> "If you don't know where you are going, you will wind up somewhere
>>>>> else."
>>>>> Lawrence Peter Berra
>>>>>
>>> --
>>> art fougner, md
>>>
>>> "If you don't know where you are going, you will wind up somewhere
>>> else."
>>> Lawrence Peter Berra
>>>
>
> --
> art fougner, md
>
> "If you don't know where you are going, you will wind up somewhere else."
> Lawrence Peter Berra
>
