Re: OB: Good, Bad, Or Ugly?
From: art fougner, md (evsono@pipeline.com)
Wed Aug 17 10:04:38 2005
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I used to respect the New York Times ...
art
At Wed, 17 Aug 2005, Charlie Chambers wrote:
>
>I did see that. Of course, I like that it was published ONLINE. Not
>exactly my most respected journal.
>************************************************************************
>****
>************************************************************************
>
>--
>Charlie Chambers
>Hood River, OR
>cchamber@alumni.rice.edu
>
>"Almost anything you do will seem insignificant but it is very important
>that you do it....You must be the change you wish to see in the world"
> -- Mahatma Ghandi.
>************************************************************************
>*******
>************************************************************************
>
>On Aug 17, 2005, at 7:16 AM, art fougner, md wrote:
>
>> The company website has a reference section, among which is this:
>>
>> Fetal DNA detection in maternal plasma throughout gestation
>> Received: 1 March 2005 Accepted: 16 April 2005 Published online: 20 May
>> 2005
>>
>> Abstract The presence of fetal DNA in maternal plasma may represent a
>> source of genetic material which can be obtained noninvasively. We
>> wanted to assess whether fetal DNA is detectable in all pregnant women,
>> to define the range and distribution of fetal DNA concentration at
>> different gestational ages, to identify the optimal period to obtain a
>> maternal blood sample yielding an adequate amount of fetal DNA for
>> prenatal diagnosis, and to evaluate accuracy and predictive values of
>> this approach. This information is crucial to develop safe and
>> reliable
>> non-invasive genetic testing in early pregnancy and monitoring of
>> pregnancy complications in late gestation. Fetal DNA quantification in
>> maternal plasma was carried out by real-time PCR on the SRY gene in
>> male-bearing pregnancies to distinguish between maternal and fetal DNA.
>> A cohort of 1,837 pregnant women was investigated. Fetal DNA could be
>> detected from the sixth week and could be retrieved at any gestational
>> week. No false-positive results were obtained in 163 women with
>> previous embryo loss or previous male babies. Fetal DNA analysis
>> performed blindly on a subset of 464 women displayed 99.4, 97.8 and
>> 100%
>> accuracy in fetal gender determination during the first, second, and
>> third trimester of pregnancy, respectively. No SRY amplification was
>> obtained in seven out of the 246 (2.8%) male-bearing pregnancies.
>> Fetal
>> DNA from maternal plasma seems to be an adequate and reliable source of
>> genetic material for a noninvasive prenatal diagnostic approach.
>>
>> Silvia Galbiati1, Maddalena Smid2, Dania Gambini2, Augusto Ferrari2,
>> Gabriella Restagno3, Elsa Viora4, Mario Campogrande4, Simona
>> Bastonero4,
>> Marco Pagliano5, Stefano Calza6, Maurizio Ferrari1, 7 and Laura
>> Cremonesi1
>>
>> (1) Unit of Genomics for Diagnosis of Human Pathologies, IRCCS H. San
>> Raffaele, Via Olgettina 58, 20132 Milan, Italy
>> (2) Department of Obstetrics and Gynecology, IRCCS H. San Raffaele,
>> Milan, Italy
>> (3) Struttura Complessa Genetica Molecolare, A.O.O.I.R.M.-S. Anna,
>> Torino, Italy
>> (4) Centro di Ecografia e Diagnosi Prenatale, Ospedale S. Anna,
>> Torino,
>> Italy
>> (5) Cattedra A, Università di Torino, Torino, Italy
>> (6) Sezione di Statistica Medica e Biometria, Dipartimento di Scienze
>> Biomediche e Biotecnologie, Università di Brescia, Brescia, Italy
>> (7) Diagnostica e Ricerca S. Raffaele S.p.A., H. San Raffaele, Milan,
>> Italy
>>
>> Source http://www.springerlink.com
>>
>> art
>>
>> At Wed, 17 Aug 2005, Charlie Chambers wrote:
>>>
>>> I think it shows what a rush we are in as a society. Willingness to
>>> spend this kind of money when you will know for certain at delivery.
>>> Also, to date, I can't recall off hand any studies that were 100%
>>> accurate in terms of prediction when using probes for Y chromosome
>>> sequences in maternal blood.
>>>
>>> **********************************************************************
>>> **
>>> **********************************************************************
>>> ****
>>>
>>> --
>>> **********************************************************************
>>> **
>>> **********************************************************************
>>> Charlie Chambers
>>> Hood River, OR USA
>>> cchamber@alumni.rice.edu
>>>
>>> "...not because I regard fishing as being so terribly
>>> important but because I suspect that so many of the other
>>> concerns of men are equally unimportant-and not nearly
>>> so much fun."
>>> John Voelker
>>> **********************************************************************
>>> **
>>> **********************************************************************
>>> *****
>>> **********************************************************************
>>> **
>>> **********************************************************************
>>> On Aug 17, 2005, at 5:17 AM, art fougner, md wrote:
>>>
>>>> Kit makes it womb with a view
>>>>
>>>> BY MAGGIE HABERMAN
>>>> DAILY NEWS STAFF WRITER
>>>>
>>>> Forget about sonograms and amniocentesis tests - a new take-home kit
>>>> allows expectant moms to find out their baby's gender as early as
>>>> five
>>>> weeks into their pregnancy.
>>>>
>>>> "People just want to plan ahead, and this allows them to plan ahead
>>>> even
>>>> further," said Sherry Bonelli, president of pregnancystore.com, the
>>>> online outlet selling the Baby Gender Mentor.
>>>>
>>>> Parents who buy the $25 kit get a tool to prick their fingers for a
>>>> small blood sample that is sent to a lab in Massachusetts.
>>>>
>>>> For $250 in lab fees, the results come within 48 hours.
>>>>
>>>> The lab techs identify the baby's DNA in the mother's blood. If
>>>> there's
>>>> a Y chromosome found, parents can start buying blue onesies; if there
>>>> isn't, it's pink wallpaper for the nursery.
>>>>
>>>> Bonelli said she has sold thousands of kits since they became
>>>> available
>>>> in June. Some couples want to prepare siblings for the arrival of a
>>>> baby; one engaged couple wanted to coordinate their wedding favors
>>>> with
>>>> their unborn child's sex, she added.
>>>>
>>>> But some bioethicists fear that since the test is taken while the
>>>> embryo
>>>> is so unformed, some people will use it to end early pregnancies if
>>>> they
>>>> don't get the boy or girl they were hoping for.
>>>>
>>>> http://www.nydailynews.com/08-16-2005/city_life/story/337700p
>>>> -288375c.html
>>>>
>>>> art
>>>>
>>>> --
>>>> art fougner, md
>>>>
>>>> "If you don't know where you are going, you will wind up somewhere
>>>> else."
>>>> Lawrence Peter Berra
>>>>
>> --
>> art fougner, md
>>
>> "If you don't know where you are going, you will wind up somewhere
>> else."
>> Lawrence Peter Berra
>>
--
art fougner, md
"If you don't know where you are going, you will wind up somewhere else."
Lawrence Peter Berra
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