Re: Methotrexate

From: R. Daniel Braun (rd.braun@gmail.com)
Fri Mar 18 19:53:56 2005


My point was not that the lower dose was safe, it was that the lower dose could not be counted on to induce abortion..

On Fri, 18 Mar 2005 20:24:18 -0600, Julio Arellano <arellano@netverk.com.ar> wrote: >
> Dear colleagues:
>
> We´ve used methotrexate as a conservative option in two cases of ectopic
> pregnancy, in cervical and cornual (interstitial) location. In both cases
> the dose was 1 mg/kg/day, and it shows as a succesfully alternative to
> surgical treatment, with a mild abdominal pain and minimal vaginal bleeding
> in the cervical.
> Anyway, methotrexate interferes with DNA synthesis and thus is teratogenic,
> so I´m not sure if an
> 'threshold' or 'safe' dose can be determined.
>
> Julio C Arellano, MD
>
> La Plata. Bs As
>
> Argentina.
>
> -------Mensaje original-------
>
> De: R. Daniel Braun
> Fecha: 03/16/05 14:55:09
> Para: Multiple recipients of list OB-GYN-L
> Asunto: Re: Methotrexate
>
> But in much HIGHER Doses.
> Dan
>
> On Wed, 16 Mar 2005 09:53:30 -0600, alejandro.morales@cecla.com
> <alejandro.morales@cecla.com> wrote:
> >
> > Remember that methotrexate has been used in ectopic pregnancy as a medical
> > (non surgical) option.
> >
> > ALEJANDRO MORALES DEL OLMO MD
> >
> > RreyANP@aol.com
> > Enviado por:
> > ob-gyn-l@obgyn.n
> > et
> > 16/03/2005 12:11 Para:
> > a.m. Multiple recipients of
> list OB-GYN-L <ob-gyn-l@dns.obgyn.net>
> > Por favor,
> > responda a
> > ob-gyn-l cc:
> >
> > Asunto:
> > Methotrexate
> >
> > Hi all,
> > What's been your experience with Methotrexate in early pregnancy. I have a
> > patient who was taking Methotrexate for rheumatoid arthritis. Her last
> dose
> > (15mg) was Feb 12 and she found out she was unexpectedly pregnant.
> >
> > Your thoughts are appreciated.
> >
> > Abby, NP
> >
>
> --
> R. Daniel Braun
> Kinky for Governor
>

--
R. Daniel Braun
       Kinky for Governor




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