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Re: GYN: Menostar From: Charlie Chambers (cchamber@gorge.net) Wed Sep 29 13:42:40 2004 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Garry E. Siegel, M.D.: "Re: GYN: Menostar" Previous message: RModugno@aol.com: "Re: GYN: Menostar" In reply to: RModugno@aol.com: "Re: GYN: Menostar" Next in thread: Garry E. Siegel, M.D.: "Re: GYN: Menostar" Reply: Garry E. Siegel, M.D.: "Re: GYN: Menostar" Two years doesn't seem long enough to feel confident about hyperplasia incidents. Plus, no meaningful fracture data. Would be a lot more helpful if these companies that are putting forth new meds for osteo to get some fracture data instead of quick BMD data. On Sep 29, 2004, at 11:24 AM, RModugno@aol.com wrote: > > In a message dated 9/29/04 12:14:35 AM Eastern Daylight Time, > zbnewton@bellsouth.net writes: > The limiting issue is the outlier who develops an endometrial > malignancy > while under such a regimen that has not been standardized  The > liability > issue will devastate the prescriber, regardless of benefit/risk > arguments. > > If the uterus is there with estrogen therapy, progesterone/progestin > additive on a standardized basis is obligatory. By today's standards, > p-therapy every 4 or 6 months for the individual who does develop > endometrial carcinoma will come back to bite you. > > Zach Newton > Z. B. Newton, III, M.D. > Atlanta/ Gyn > Zach, this comes from Berlex: >   > > "Menostar is a fundamentally new approach to post-menopausal > osteoporosis prevention. In a two-year clinical study, Menostar, with > a very low dose of estrogen, did not increase the risk of endometrial > hyperplasia among women with a uterus. Therefore, this patch does not > require a daily or monthly concomitant progestin," said Marie Foegh, > M.D., Vice President, Medical Affairs for Berlex Laboratories. "Until > now, we in the medical community never knew such small amounts of > estrogen could help maintain bone health. With Menostar, we can return > a woman's estrogen to the lowest level proven to prevent bone loss." > > I would suggest, therefore, that a 4 to 6 month progesterone > "challenge' is acceptable therapy. > > Robert Modugno Md MBA FACOG > > Marietta, GA > > http://www.novaobgyn.yourmd.com > >   > ************************************************************************ **** Charlie Chambers Hood River, OR USA cchamber@alumni.rice.edu "...not because I regard fishing as being so terribly important but because I suspect that so many of the other concerns of men are equally unimportant-and not nearly so much fun." John Voelker ************************************************************************ ***** Next message: Garry E. Siegel, M.D.: "Re: GYN: Menostar" Previous message: RModugno@aol.com: "Re: GYN: Menostar" In reply to: RModugno@aol.com: "Re: GYN: Menostar" Next in thread: Garry E. Siegel, M.D.: "Re: GYN: Menostar" Reply: Garry E. Siegel, M.D.: "Re: GYN: Menostar"

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