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Re: GYN: MenostarFrom: RModugno@aol.comWed Sep 29 13:23:16 2004
In a message dated 9/29/04 12:14:35 AM Eastern Daylight Time, zbnewton@bellsouth.net writes: The limiting issue is the outlier who develops an endometrial malignancy while under such a regimen that has not been standardized The liability issue will devastate the prescriber, regardless of benefit/risk arguments. If the uterus is there with estrogen therapy, progesterone/progestin additive on a standardized basis is obligatory. By today's standards, p-therapy every 4 or 6 months for the individual who does develop endometrial carcinoma will come back to bite you. Zach Newton Z. B. Newton, III, M.D. Atlanta/ Gyn Zach, this comes from Berlex: "Menostar is a fundamentally new approach to post-menopausal osteoporosis prevention. In a two-year clinical study, Menostar, with a very low dose of estrogen, did not increase the risk of endometrial hyperplasia among women with a uterus. Therefore, this patch does not require a daily or monthly concomitant progestin," said Marie Foegh, M.D., Vice President, Medical Affairs for Berlex Laboratories. "Until now, we in the medical community never knew such small amounts of estrogen could help maintain bone health. With Menostar, we can return a woman's estrogen to the lowest level proven to prevent bone loss." I would suggest, therefore, that a 4 to 6 month progesterone "challenge' is acceptable therapy. Robert Modugno Md MBA FACOG Marietta, GA http://www.novaobgyn.yourmd.com
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