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Re: BMJ Another HRT trial is stopped early From: DoctorJoe@aol.com Fri Feb 6 07:32:19 2004 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Braun, R. Daniel: "Re: !st Trimester Screening For Downs" Previous message: Dean Huffman: "!st Trimester Screening For Downs" Maybe in reply to: Gail Waldby: "BMJ Another HRT trial is stopped early" In a message dated 2/6/04 05:34:26, rbraun@iupui.edu writes: > We seem to be getting so ethical that we can't complete any studies far > enough along to get any real scientific information. > 89 of 450 women (20%) who were randomized were excluded from the > analysis. This news report here doesn't tell us why. It tells us another > trial was stopped and then gives the confidence interval for that study > and they crossed 1. WOW. > > R. Daniel Braun, MD > Hmmmm. You design a study because the therapy MIGHT work. However, the study may be unethical for two reasons: 1) The proposed therapy might NOT work, in fact it may produce harm; 2) The proposed therapy might actually work, and that means the placebo group is getting subquality care, i.e. be harmed. And of course we all know, "first, do no harm." Go figure. Joe P. Next message: Braun, R. Daniel: "Re: !st Trimester Screening For Downs" Previous message: Dean Huffman: "!st Trimester Screening For Downs" Maybe in reply to: Gail Waldby: "BMJ Another HRT trial is stopped early"

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