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Re: Erythropoietin From: Dr James Lie (splaz@cyllene.uwa.edu.au) Sun Jan 25 18:11:40 2004 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: Douglas Krell: "Re: Thoughts on management" Previous message: Joanne Bulley, MD: "Re: Thoughts on management" In reply to: Gail Waldby: "Re: Erythropoietin" Next in thread: Braun, R. Daniel: "Re: Erythropoietin" 1. EPO is administered twice or thrice weekly, intravenously or (more usually) subcutaneously. The principal side effect is impaired control of hypertension. Body iron stores are critical in maintaining the erythropoietic response. Parenteral iron saccharate can reduce the maintenance dose of EPO. 2. however there is no evidence that once weekly is any worse than 2/3 times a week, see Cochrane's review: http://www.update-software.com/abstracts/AB003895.htm 3. and Tarng et Huang http://ndt.oupjournals.org/cgi/content/abstract/13/11/2867 found that it is iv vitamin C rather than iron that increases iron utilisation in the erythron. 4. re length of time - see case presentation: http://www.blackwell-synergy.com/links/doi/10.1046/j.1460-9592.2003.01012.x/ abs/ Hb33 - EPO given for 4 days before surgery and 10 days postop. 5. an unsourced quote: "Patients who receive six shots of erythropoietin in the weeks before surgery have the equivalent of two extra pints of blood in their body when they enter the operating room" -- James Lie Australia -----Original Message----- From: ob-gyn-l@obgyn.net [mailto:ob-gyn-l@obgyn.net]On Behalf Of Gail Waldby Sent: Monday, 26 January 2004 12:33 AM To: Multiple recipients of list OB-GYN-L Subject: Re: Erythropoietin Gerald, you are correct. You must supplement iron also, probably in this case IV. Gail Waldby, MD Huron SD Gerald P. Rodríguez wrote: >I must admit I don't know the specific answer to your question, and I am >going to guess that there is little experience with this remedy for blood >loss anemia. Seems to me, though, that erythropoietin would have little to >no effect in stimulating RBC production if her iron stores are severely to >totally depleted. > >Gerald UP. Rodríguez, ME.DO., FACING >Santa Fe > >>----- Original Message ----- >From: "Steve & Eryl Raymond" <eryl@intekom.co.za> >To: "Multiple recipients of list OB-GYN-L" <ob-gyn-l@dns.obgyn.net> >Sent: Sunday, January 25, 2004 6:53 AM >Subject: Erythropoietin > >>One of Jehovah's Witnesses was admitted the other day with severe >>menorrhagia and a Haemoglobin of 3. The cabal that surrouns her want >>her to have erythropoietin, and are very keen to buy it for her. As she >>has now stopped bleeding for a couple of days I am relaxed about her >>anaemia as it is asymptomatic. But, how quickly will her haemoglobin >>rise if I do get this for her,and how much does she need? Anyone used >>it and can answer me? >>-- >>S.H. Raymond FRCOG >>Principal Specialist >>Department of Obstetrics & Gynaecology >>Empangeni Hospital >>Private Bag X20005 >>Empangeni >>SOUTH AFRICA 3880 >> >>Phone: (+27)-35-9028560 >>Fax: (+27)-35-7922596 >> >>Everyone thinks of changing the world, but no one thinks of changing >>himself. >>Leo Tolstoy (1828-1910) >> > Next message: Douglas Krell: "Re: Thoughts on management" Previous message: Joanne Bulley, MD: "Re: Thoughts on management" In reply to: Gail Waldby: "Re: Erythropoietin" Next in thread: Braun, R. Daniel: "Re: Erythropoietin"

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