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Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2From: ATB28@aol.comWed Jun 14 19:19:09 2000
In a message dated 06/14/2000 4:23:13 PM Pacific Daylight Time, mperloe@ivf.com writes: << Screen the aunt (proband) who is alive with breast Ca for BRCA 1/2 mutations. If she is negative, then this it is not likely a detectable Ca family and although risk is very high, screening the patient won't help. Patient will consider removal of ovary to avoid passing risk and need to take OC's which may increase risk of breast ca. Will also consider prophylactic mastectomy with breast surgeon. If the aunt is BRCA 1/2 mutation positive, then screen the patient (consultand), if positive, she plans mastectomy and should consider prophylactic oophorectomy... >> BRCA sequencing and mutation analysis is appropriate as noted above. Allan T. Bombard, MD Oakland, CA
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