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Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2 From: Gail Waldby (gwaldby@willinet.net) Wed Jun 14 19:16:10 2000 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: ATB28@aol.com: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2" Previous message: Braun, R. Daniel: "Re: GEN: Communication" Maybe in reply to: LUCA SAVELLI: "Recurrent ovarian cysts, breast CA and BRC1 BRC2" Next in thread: Mark Perloe: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2" Reply: Mark Perloe: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2" If the aunt is negative for BRCA mutations, I would still try to get preserved material from the dead relatives with breast cancer, because the aunt could have a sporadic breast cancer even if the other relatives had BRCA mutations. Gail Waldby, MD Huron Clinic SD Mark Perloe wrote: > > 22 year old female G0, s/p resection Rt ovary 4 years ago dermoid cyst. > 1999 two hemorrhagic cysts removed from the L ovary. Now 4 cm irregular > cyst measuring 5cm mildly painful. She has been on OC's to prevent cysts. > > But the picture gets more complicated. 11 relatives with breast cancer on > one side of the family, all except one are dead. All got it before age 40. > Mom dead at age 38. Other side of family, one breast and one ovarian cancer. > > Questions from patient: > 1. Should the ovary be removed to avoid passing on high risk of breast CA > to female offspring? > 2. Would testing her for BRC1 & 2 help? > 3. Should she avoid birth control pills? > > Well here is my take. Open for any comments. > Screen the aunt who is alive with breast Ca. If she is negative, then this > is not likely a detectable Ca family and risk is very high, but screening > patient won't help. Patient will consider removal of ovary to avoid passing > risk and need to take OC's which may increase risk of breast ca. Will also > consider prophylactic mastectomy with breast surgeon. > > If the aunt is positive, she will be screened, if positive, she plans > mastectomy and conservative ovarian surgery with subsequent IVF with embryo > biopsy and PCR for the affected gene. > Mark Perloe, M.D. http://www.ivf.com 404-843-2229 x110 > 5445 Meridian Mark Road, Atlanta GA 30342 > Online Chat Monday Evenings 8-9:30pm ET http://www.ivf.com/chat.html Next message: ATB28@aol.com: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2" Previous message: Braun, R. Daniel: "Re: GEN: Communication" Maybe in reply to: LUCA SAVELLI: "Recurrent ovarian cysts, breast CA and BRC1 BRC2" Next in thread: Mark Perloe: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2" Reply: Mark Perloe: "Re: Recurrent ovarian cysts, breast CA and BRC1 BRC2"

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