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Clear Laps - occult endometriosis and autoflourescence techniqueFrom: Nala (anonymous@obgyn.net)Thu Apr 24 08:47:00 2008
Hello ladies, There is this thing I can across about 'occult endometriosis'. It is a form of endo that cannot be seen on a laparoscopy (NB: it must be said that some experts such as Redwine do not believe in this). However, there is a new type of laparoscopy being trialled in the US and Germany where they use a different kind of light that shows these 'occult areas' that cannot otherwise be seen. It would be interesting to get more studies as I have had 2 clear laps and unbelievable pain that is only helped by progesterone or GNRH therapy. It might provide some explanation. Here is the info anyway:
>From the US: http://www.gcivf.com/news3.html And from Germany, this abstract: Detection of peritoneal endometriotic lesions by autofluorescence laparoscopy Olaf Buchweitz MDa, Annette Staebler MDb, Joke Tio MDa and Ludwig Kiesel MDa aDepartments of Obstetrics and Gynaecology bPathology, University of Münster, Münster, Germany Received 28 November 2005; revised 24 January 2006; accepted 27 February 2006. Available online 3 May 2006. Objective This study was undertaken to evaluate the feasibility of autofluorescence laparoscopy in the diagnosis of endometriotic lesions. Study design Prospective analysis of 83 consecutive patients undergoing laparoscopy for suspected endometriosis under white light illumination and autofluorescence diagnosis. the study measured total number of endometriotic lesions diagnosed under white light illumination and with autofluorescence diagnosis. Results The biopsy-based sensitivity of white light diagnosis alone and white light illumination and autofluorescence for detecting nonpigmented peritoneal endometriotic lesions was 65% compared with 92% (1.42-fold increase). The corresponding specificity was 68% as opposed to 84%. Occult areas of endometriosis were discovered using autofluorescence diagnosis. Statistical analysis was performed with χ2 test and McNemar test. Conclusion Combination of white light illumination and autofluorescence is significantly superior to white light ilumination alone in detecting nonpigmented endometriotic lesions. Autofluorescence diagnosis of nonpigmented endometriotic lesions may become an alternative to fluorescence diagnosis after application of 5-aminolevulinic acid, especially because of no side effects. Key words: Fluorescence diagnosis; Endometriosis; Peritoneal endometriosis; Autofluorescence; 5-aminolevulinic acid American Journal of Obstetrics and Gynecology Volume 195, Issue 4, October 2006, Pages 949-954
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