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to MichelleFrom: andrea (anonymous@obgyn.net)Wed Oct 17 00:05:51 2007
At Wed, 17 Oct 2007, andrea wrote: > >Michelle, > >I'm so sorry for all you are going through, I can't imagine how hard it >must be. When I first joined this site, I thought my problems were bad, >but to see so many women on here sick from Lupron makes my cramps seem >minor. I've had tons of doctors pressure me to take it, but I've always >refused. I really do want to fight for all of you with Lupron >illnesses, I just hope I can. Please e-mail me, so we can keep in touch >& I can keep you updated on things. > >Take care of yourself, >Andrea > >At Tue, 16 Oct 2007, Michelle wrote: >> >>Hmmm...very interesting. I developed my pituitary microadenoma in the >>years after taking Lupron in 1997. The idea that Lupron could lead to >>pituitary disease sounds very plausible to me because the drug so >>artificially and abnormally hyperstimulates the pituitary gland to >>produce FSH that I'm sure damage could easily occur to this tiny gland. >>Further, I have been told I have a "nonfunctional" pituitary adenoma >>which tumors typically arise from abnormal cells of the gonadotroph >>variety. The tumor has grown 4mm in size and is almost a macroadenoma >>now, growing at a rate of 1mm+ per year. I will probably have to have >>pituitary surgery some year soon. Also, I have adrenal insufficiency >>that I believe is due in part to this pituitary tumor, which has almost >>killed me three times now with adrenal crises. With a nonfunctional >>adenoma, you can end up with adrenal problems, thryoid problems, >>gynecologic problems, etc., such as mine because the abnormal tissue in >>the pituitary continues to grow over time, displacing the normal >>pituitary tissue and that is how you end up with a virtual >>hypophysectomy because the normal pituitary cells are destroyed and >>replaced by the abnormal ones and the pituitary therefore loses the >>ability to produce the pituitary stimulating hormones such as ACTH, FHS, >>TSH, GH, and so one, that stimulate the adrenals, thyroid, etc. >> >>I truly believe that the link between Lupron and pituitary problems >>should be studied further. Also, I think that researchers and doctors >>should be much more attentive to the side effects of long-term use of >>estrogen/progestin pills for endometriosis. I believe that I have >>suffered a lot of damage from these pills. For years, they caused >>numbness in my arms, sharp head pains, and other such symptoms. I have >>evidence of small infarcts, liver damage, and pulmonary hypertension >>now. I believe the pills played some role in much of this, based on my >>symptoms. Doctors should not dismiss offhand, as mine did, the >>complaints of a patient with regard to such symptoms as I now know they >>are quite serious. Focal nodular hyperplasia in the liver, sharp head >>pain and evidence of microvascular disease in the brain, Raynauds, heart >>strain, nonspecific ischemia, shortness of breath, and so on, should all >>be taken seriously and not dismissed. Instead, doctors are waiting for >>a major stroke or heart attack to occur before they take any complaints >>seriously. By then, it's too late. >> >>Stay vigilent everyone. And thanks for the post. Interesting. >> >>At Tue, 16 Oct 2007, andrea wrote: >>> >>>These quotes are from the PDF that Maggie found of testimony of a nurse, >>>Lynne Millican, to the Senate, who became ill from Lupron 10 years ago. >>> >>>I also spoke with Emily Page, the woman who started the Lupron petition, >>>and she also believes there is a cover-up going on when it comes to >>>Lupron. She sued TAP, but was given very little money, because her >>>doctor denied her problems were caused by the Lupron. She is still very >>>sick today. >>> >>>Please read these outtakes, and see what you think....falsifying 80% of >>>info in 4 Lupron studies? That sounds like a cover-up to me.... >>> >>>pg 54: TAP has been declared a criminal enterprise based upon its scheme >>>with physicians and billing fraud and kickbacks and they just paid the >>>largest fine in history at the time, $875 million. >>> >>>pg 58: The internet posts of women identify the badgering, and coercion, >>>and manipulation, and threats used to convince women into taking Lupron >>>for a variety of indications—many refer to their doctor as trying to >>>‘‘shove it down [their] throat’’. >>> >>>pg 58: I would later learn that the director of this IVF clinic, Dr. >>>Andrew Friedman, had been a lead Lupron investigator, had received >>>numerous grants and funds from Lupron’s manufacturer, Takeda Abbott >>>Pharmaceuticals (TAP), and had published extensively on Lupron. Dr. >>>Friedman was ultimately found guilty of falsifying and fabricating >>>approximately 80 percent of the data in four Lupron studies, two of >>>which had been published and were subsequently retracted. Friedman had >>>‘‘altered and fabricated information in patient medical records, >>>falsified research notes by changing dates and changing and adding >>>text’’, and fabricated notes and fabricated patients for clinical visits >>>that had not taken place. >>> >>>pg 61: The profoundly significant and despicable thefts (‘‘conversion’’, >>>‘‘sharing’’) of women’s ova and embryos by Drs. Ricardo Asch, Sergio >>>Stone and Jose Balmaceda at the University of California at Irvine >>>(Regents; Press; 1995) should be a serious reminder to the utter (and >>>anesthetized) ease with which such menacing maneuvers can be executed. >>>(And Dr. Asch had co-authored studies of Lupron, ‘‘which was kindly >>>provided by Abbott’’ [Guerrero, 1993]). The contemptible violations of >>>stealing women’s eggs and embryos should highlight the profitability of >>>schemes to procure women’s eggs and embryos for use in research and/or >>>covert ‘re-sale’. Dr. Asch reportedly ‘left his office daily with >>>briefcase stuffed with thousands of dollars’. And attention should be >>>directed to the drug protocol(s) used—medications administered >>>‘‘deliberately’’ ‘‘so there would be a surplus of eggs’’ (Challender, >>>1995). Who is exerting any oversight over the field of reproductivity? >>>Who would exert oversight over therapeutic cloning—this same industry? >>> >>>pg 63: Women are told that Lupron will ‘‘shut down their system’’, >>>allowing ‘‘control’’ over their system, and that the side effects are >>>related to menopausal symptoms. But in fact, it was known prior to my >>>‘treatment’ with Lupron (but not disclosed to me) that Lupron causes a >>>‘‘hypophysectomy’’ (Holmes, 1988)—which, by definition, is ‘‘destruction >>>or removal of the pituitary’’; and it was known (but not disclosed to >>>me) that ‘‘sustained treatment with GnRH agonists most likely abolishes >>>pituitary function’’ (Bischof, 1988). I would also later learn that in >>>the original rat studies submitted to the FDA for Lupron’s initial >>>approval of palliative prostate cancer, all rats at all doses developed >>>pituitary adenomas (tumors)—and it was stated that ‘‘there is no obvious >>>reason to suggest that the same process could not occur >>>in humans’’ (NDA 19–010). >>> >>>pg 65: Published medical reports have noted the occurrence of abnormal >>>human pregnancy outcomes associated with the use of Lupron—43.5 percent >>>in one 1996 study (Karande, 1996). Another report, using the ‘long >>>Lupron protocol’, showed a 38 percent abortion rate (Shanis, 1995), and >>>a study of ‘low responders’ using Lupron showed a 66.6 percent >>>spontaneous first trimester abortion rate (Droesch, 1989). In ‘healthy >>>women undergoing ovarian stimulation’ using Lupron in another study, an- >>>other 66.6 percent abortion rate was noted (Minaretzis, 1995). Another >>>study’s title states ‘‘Exposure to [Lupron] in Early Pregnancy is >>>Associated With High Pregnancy Wastage That Could be Related to the >>>Length of Exposure’’ (Sasy, 1997). >>> >>>pg 69: The U.S. investigation of TAP’s billing practices revealed that >>>a computer program given by TAP to many doctors in the country (some >>>10,000 urologists received gifts from TAP), which computated the amount >>>of money per Lupron prescription the doctor could earn, also harbored a >>>‘secret key’—and in the event the secret computer program was in danger >>>of discovery, a secret key was struck and !presto! all incriminating >>>information disappeared. >>> >>>The first long-term follow-up of children who were accidentally exposed >>>to GnRHa's was published in 1999, and revealed that 4 out of the 6 >>>children studied had severe neurodevelopmental abnormalities (including >>>seizure disorder). If that figure holds up in larger subsequent >>>follow-up of children ... I would ask - do you think there is a problem >>>here ... and what is the solution?' Archives of Ophthalmology, 2001, >>>carried an article with a telling title:Ocular Anomalies Seen in >>>Children Born After IVF'. On March 7, 2002 a new study was released >>>indicating that the former 2-3% rate of major birth defects from IVF - a >>>percentage always classified as consistent with the general population - >>>was, in fact, in error. This study now found a 9% rate of major birth >>>defects among IVF offspring. Will the percentage of birth defects from >>>IVF continue to climb? >>> >>>http://www.stemcellresearch.org/testimony/complete_hearing-2006-03.pdf
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