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Re: effectiveness of Zoladex on Endo pain From: anonymous (anonymous@obgyn.net) Tue Jan 25 17:08:53 2005 Messages sorted by: [ date ][ thread ][ subject ][ author ] Next message: anonymous: "Re: 17 and very confused" Previous message: Sara: "Re: 17 and very confused" In reply to: Lori: "Re: effectiveness of Zoladex on Endo pain" Zoladex is not a pain reliever. It is a gonadotropin see http://www.rxlist.com/cgi/generic/goserel.htm Zoladex is an LNRH agonsit vs. a GnRH agonist that is most commonly heard of here for treatment of endometriosis. Here is what it says about it's use in Endometriosis: see this page: http://www.rxlist.com/cgi/generic/goserel_ad.htm Endometriosis: In controlled clinical trials comparing ZOLADEX every 28 days and danazol daily for the treatment of endometriosis, the following events were reported at a frequency of 5% or greater: At the top of a long list is Hot Flushes with an occurence rate of 96% Vaginitis and Headache at 75% and Emotional Lability at 60% - and it just gets better ?? from there... sign me up! not Hormone Replacement Therapy: Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/pr progestins) to ZOLADEX may decrease the occurrence of vasomotor symptoms and vaginal dryness associated with hypoestrogenism without compromising the efficacy of ZOLADEX in relieving pelvic symptoms. The optimal drugs, dose and duration of treatment has not been established. Changes in Bone Mineral Density: After 6 months of ZOLADEX treatment, 109 female patients treated with ZOLADEX showed an average 4.3% decrease of vertebral trabecular bone mineral density (BMD) as compared to pretreatment values. BMD was measured by dual-photon absorptiometry or dual energy x-ray absorptiometry. Sixty-six of these patients were assessed for BMD loss 6 months after the completion (posttherapy) of the 6-month therapy period. Data from these patients showed an average 2.4% BMD loss compared to pretreatment values. Twenty-eight of the 109 patients were assessed for BMD at 12 months posttherapy. Data from these patients showed an average decrease of 2.5% in BMD compared to pretreatment values. These data suggest a possibility of partial reversibility. Clinical studies suggest the addition of Hormone Replacement Therapy (estrogens and/or progestins) to ZOLADEX is effective in reducing the bone mineral loss which occrrs with ZOLADEX alone without compromising the efficacy of ZOLADEX in relieving the symptoms of endometriosis. The optimal drugs, dose and duration of treatment has not been established. There's a lot more, I suggest you read each page thoroughly and perhaps print them out. Hope this helps! > >At Tue, 25 Jan 2005, anonymous@obgyn.net wrote: >> >>HI, i'm new here but i've visited to have a look quite a few times. >> >>I recently found out i have endo, the pain has become more intense and >>frequent for years (i just figured it was 'bad periods') and i have >>spent most of the last year absent from work due to pain. >> >>I had a lap at the end of november and have been on Zoladex since early >>december, i returned to see my consultant a week ago and he seemed to >>think that the pain i have is now nothing to do with endo because the >>Zoladex isn't getting rid of it, the pain corresponds to the site of the >>endo and has never changed yet the hospital are taking the stance that >>the pain is due to muscle spasm, this is scaring me slightly as they >>have taken me off one set of pain killers (co-codamol) and given me >>something called 'Buscopan' which is to stop muscle spasm, having read >>the included leaflet i can't find any reference to my symptoms at all. >> >>In addition to this he prescribed a hrt pill to reduce hot sweats etc >>caused by Zoladex, i have only been taking them a few days yet i am >>noticing what i used to think was ovulation and period pains and >>increased pain in general. >> >>I am going back to my GP tomorrow but i just wondered if anybody else >>has come across 'Buscopan' and or Livial HRT who maybe knows a little >>more than me?! >> >>Kind regards >>Clare > Next message: anonymous: "Re: 17 and very confused" Previous message: Sara: "Re: 17 and very confused" In reply to: Lori: "Re: effectiveness of Zoladex on Endo pain"

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