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Re: AsoprisnilFrom: Anne (anonymous@obgyn.net)Fri Jul 30 23:28:33 2004
At Thu, 3 Jun 2004, Jean wrote: > >Has anyone been able to try Asoprisnil (a selective progesterone >receptor modulator) for endo or fibroids? I think it may still only be >available in clinical trials. I've heard that it usually stops your >period while you're on it, with minimal side effects? I'd be interested >to hear about anyone's experience with it. > >-- >Jean > Jean, I too have been very excited about this promising investigative drug. So far it has has tested better than RU-486 in that it does not cause overgrowth of the endometruim and androgenic side effect. It also does not cause loss of bone density like Lupron (also TAP's drug), so can be taken long-term. It is in phase II trails for endo and phase III for fibroids. I have fibroids but already am symptomatic with inability to urinate if I let my bladder get too full, so, if my fibroids continue to grow I don't know if I can avoid surgery before this drug is approved. According to TAP labs it will be submitted to the FDA for approval in 2005, so expect it to be approved by the end of 2006 for fibroid treatment. Endo approval would probably be about a year later. If you can hang in there a few more years you might try this then. I would really like to hear from women who have been involved in the clinical trials what their experiences with any side effects were/are, since that is why I am basically scared to death of Lupron and looking for the next best drug therapy. To the doctors- what is the buzz on this drug in your circles?
-- Anne
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