ENDO Messages for July, 2004: Re: Femara and endo

Re: Femara and endo

From: Anonymous (anonymous@obgyn.net)
Mon Jul 12 12:14:50 2004

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Here's the abstract from a recent clinical trial on Femara and endo. Sounds promising!

Fertil Steril. 2004 Feb;81(2):290-6. Related Articles, Links

Treatment of endometriosis and chronic pelvic pain with letrozole and norethindrone acetate: a pilot study.

Ailawadi RK, Jobanputra S, Kataria M, Gurates B, Bulun SE.

Department of Obstetrics and Gynecology, University of Illinois at Chicago, Chicago, Illinois, USA.

OBJECTIVE: To determine the role of an aromatase inhibitor, letrozole, in the treatment of reproductive-age women with endometriosis and associated chronic pelvic pain. DESIGN: Phase 2, open-label, nonrandomized proof-of-concept study. SETTING: Outpatient tertiary-care center. PATIENT(S): Ten patients with endometriosis, all previously treated both medically and surgically, with unsatisfactory results. INTERVENTION(S): Endometriosis was diagnosed by biopsy and scored from an initial diagnostic laparoscopy performed within 1 month before treatment was begun. Oral administration of letrozole (2.5 mg), the progestin norethindrone acetate (2.5 mg), calcium citrate (1,250 mg), and vitamin D (800 IU) was done daily for 6 months. Within 1-2 months after completion of the treatment, a second-look laparoscopy was performed to score and biopsy endometriosis. MAIN OUTCOME MEASURE(S): Changes in American Society for Reproductive Medicine (ASRM) scores for endometriosis, pelvic pain assessed by visual analog scale, serum hormone levels (FSH, LH, E(2), and estrone [E(1)]), and bone density (DEXA scan). RESULT(S): No histologically demonstrable endometriosis was present in any patient during the second-look laparoscopy. ASRM and pelvic pain scores decreased significantly in response to treatment. Overall, no significant change in bone density was detected. Gonadotropin levels were not significantly altered by treatment, and although circulating E(2) and E(1) levels were reduced, the decrease was not statistically significant. CONCLUSION(S): The combination of letrozole and norethindrone acetate achieved marked reduction of laparoscopically visible and histologically confirmed endometriosis in all 10 patients and significant pain relief in nine out of 10 patients who had not responded previously to currently available treatments. On this basis, letrozole should be a candidate for the medical management of endometriosis.

Publication Types: Clinical Trial Clinical Trial, Phase II

At Mon, 12 Jul 2004, holly wrote: >
>mercy and mariah,
>thank you both for the info.
>
>mercy, i read the article, and it looks promising. i have had 2
>surgeries and lupron all since november 2002, and nothing has worked.
>the last surgery was excision, and it worked for about 10 months. so
>maybe the femara will help.
>
>mariah, i will check out the website. i'm worried that since lupron
>caused so many problems for me that femara will too. but i'll go to the
>group and lurk a bit and see what side effects the girls are having.
>
>i have the cystoscopy wednesday to see if the endo has invaded the
>bladder. if it has, then i have to decide to either get it removed or
>go on femara. otherwise, i'm going to wait on any more drugs and
>procedures. if they don't see it inside the bladder, we assume it's on
>the outside of the bladder. i can live with that for a while longer.
>
>thanks again. i'll check out that group.
>
>(((hugs)))
>~holly
>
>At Mon, 12 Jul 2004, anonymous@obgyn.net wrote:
>>
>>I have been on Femara for the last three months -- if you are interested
>>in learning more about some different ladies' first-hand experiences,
>>you can join our yahoo group that we created for women who are trying
>>this drug for endo -- go to this link if you're interested.
>>
>>http://health.groups.yahoo.com/group/startingletrozole/
>>
>>For me, at least, it is definately promising -- it's already had a
>>significant effect, and I hope very much that my imporvement continues!
>>-Mariah
>>
>>At Sun, 11 Jul 2004, Mercy wrote:
>>>
>>>Holly, this is all that I was able to find on Femara so far (from
>>>WebMD). I'll keep looking...check out this link
>>>http://my.webmd.com/content/article/82/97197.htm
>>>
>--
>holly
>mild endo and IC
>

Next message: Amy: "Re: I just need to vent/ Is this normal-To Tiana and Wendy"
Previous message: Mercy: "Re: Link between synthroid and worsening symptoms"
In reply to: holly: "Re: Holly re: Femara and endo inside the bladder"
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