Re: Endometriosis and IVF
From: Drew (anonymous@obgyn.net)
Wed Jan 28 21:45:25 2004
Thanks anonymous!
I have also read about `Natural Killer Cells' or something like that
which endometriosis patients releases to `attack' the embryo whilst it
is trying to implant, but when I raised this issue with the
Embryologists at my clinic they either have no idea what I was talking
about, or maybe it is too `intense' to discuss with me since it was ONLY
my second trial. I will persevere but thanks so much for responding to
me, I will definitely raise this enzyme issue with my doctor.
Cheers, Drew
At Wed, 28 Jan 2004, anonymous wrote:
>
>Drew,
>
>I have read that some doctors think that the reason that endo can cause
>infertility is due to a lack of a certain enzyme that is necessary for
>an embryo to attach itself to the wall of the uterus that a lot of women
>with endo apparantly lack. So in a lot of cases, the woman with endo
>can make a good embryo, but due to lacking this enzyme, the embryo
>cannot attach to the uterus and is therefore flushed out of the body.
>What I was reading said that this is a new discovery and they are hoping
>to create a synthetic form of the enzyme to administer to women with
>endo who are experiencing infertility with the hopes that it will allow
>successful implantation of the embryo. I am sorry that I cannot
>remember where I read this, but perhaps you could research it or at
>least ask your doctor about it.
>
>God Bless!!
>
>At Tue, 27 Jan 2004, Drew wrote:
>>
>>I am a 30 year who had been diagnosed with Endometriosis (Stage III) for
>>two years now. I am unable to conceive naturally since my left ovary is
>>totally tied down with adhesions, and my right ovary doesn't seem to
>>function at all even though it looks `pristine'. Although I count
>>myself as one of the lucky ones since I don't experience much pain
>>associated with Endo(except for tingly pains prior to my period - but
>>not severe enough to require medication), I am plauged with the fact
>>that I cannot conceive naturally.
>>
>>I attempted IVF for the first time last year. I `grew' 6 eggs good
>>sized eggs, all of them fertilised successfully, in fact 4 of them was
>>classed `Grade 1' embroyos, and the remainly two as `Grade 2'. I have
>>been assured by the clinic that this is `good'. However the two
>>subsequent separate transfers of the embryos failed implant. The first
>>transfer was a 4-cell embryo, I experienced very intense `contraction'
>>pains and bled profusely one week after the transfer. The second
>>transfer was an 8-cell embryo, I bled on the second week post transfer,
>>and by the end of the second week I had a full-on period, blood tests
>>indicated HCG = 2 and P4 levels are high enough (normal).
>>
>>My question is has anybody here had `good' embroyos, and has a history
>>of endometriosis? If the embryos are supposingly in good shape, is there
>>a reason why they won't implant or is there something wrong with my
>>uterus?? Should I get checked out for this?
![[ endo@obgyn.net ]](../../images/endo_at_obgyn.gif)